ID A0A1L9TX08_9EURO Unreviewed; 938 AA.
AC A0A1L9TX08;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN ORFNames=ASPSYDRAFT_83846 {ECO:0000313|EMBL:OJJ63803.1};
OS Aspergillus sydowii CBS 593.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036612 {ECO:0000313|EMBL:OJJ63803.1, ECO:0000313|Proteomes:UP000184356};
RN [1] {ECO:0000313|Proteomes:UP000184356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 593.65 {ECO:0000313|Proteomes:UP000184356};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR EMBL; KV878582; OJJ63803.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9TX08; -.
DR STRING; 1036612.A0A1L9TX08; -.
DR VEuPathDB; FungiDB:ASPSYDRAFT_83846; -.
DR OrthoDB; 276400at2759; -.
DR Proteomes; UP000184356; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000184356}.
FT DOMAIN 32..109
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 334..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..398
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 105294 MW; 256675654F44E1DC CRC64;
MEWQPQEEPL GQLAYCLRDS LNSYNSAAQK QAEQMLEQAT SSPDYVNYIT YLFCTPQKPA
VLNLQAAEYD MVRFAAAMNL KTKIHIAYNT IPQDSLAYIR SATLIGLRDN NAQVRNSAGI
VITELISKAG LLAWPEVLHE LLNLVENSSG DAATTTREAA MSALFKVCED NRRILERDYS
GQCPLDVIIP KLLSFSSIES FRIRESALKA VLIFLPHRPK ALLAQMDVFL SQLFQLSNDS
SLEVQRTVCQ AFAQLVDFAP EKLVPHMEGL VNYIIMQQQS QIDPELNLDA AEFWLVAGEQ
AALQQPLAPH MTKIVPVLLQ SMVYDEEEAI RLAGEGDDAD VEDREEDLKP QFARSKAGRL
DTTKNAGQQN GDAQAAPQEE DDDLSEGEIE DSEFGDDPED EWTLRKCSAA ALDVFSNVYH
EPIFEVILPY LKETLRHEQW VQREAAVLTL GAVADGCMDA VTPHLPELVP YLISLLNDSQ
PVVRQITCWC LGRYSEWASH IAEPSERARF FEPMMEGILR RMLDGNKKVQ EAAASAFASL
EEKSDANLIP YCEPILRQFV LCFGKYKDRN MYILYDCVQT LAECVMGELA KPQLVDILMP
ALIDRYNKVS DQSRELFPLL ECLGYVAAAY GDAFAPFAPP LFQRCIKIIY ENLQEYMNSV
NNHTIDEPDK DFLVTSLDLL SAIIQAIDPN KSGELVANSQ PRFFDLLCFC MQDPNYEVRQ
SSYALLGDCA INIFPQLDQF TNELVPILIK QLDLDLIRDD DRHTGFSVLN NACWSCGEIA
VNEKAALAPY ADKLYQGLLS IINNEEIIDS VNENAAMALG RLGICCSDQL APRLAEYAGT
FLKSMNKIDF TREKASAFLG FNQVVMRNPA AMESYLGGYF QAIAAFPGKS LHQDEFQDIQ
SSFQQVLQGY KNMIPDFDSF MTQLPPPVVQ KLRSVYQI
//
