ID A0A1L9TYN9_9EURO Unreviewed; 1272 AA.
AC A0A1L9TYN9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=ASPSYDRAFT_39292 {ECO:0000313|EMBL:OJJ64557.1};
OS Aspergillus sydowii CBS 593.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036612 {ECO:0000313|EMBL:OJJ64557.1, ECO:0000313|Proteomes:UP000184356};
RN [1] {ECO:0000313|Proteomes:UP000184356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 593.65 {ECO:0000313|Proteomes:UP000184356};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; KV878582; OJJ64557.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9TYN9; -.
DR STRING; 1036612.A0A1L9TYN9; -.
DR VEuPathDB; FungiDB:ASPSYDRAFT_39292; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000184356; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184356};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 266..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1212..1235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 594..768
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1272 AA; 139747 MW; DDC55B5FDE6DBB1F CRC64;
MRGLRFIPIA AALGFPSQSV AQGETKSHEE GRCAIRGHCG KQSFFGGELP CPDNGLAEEP
EAAVRKKLVD LCGTKWEEGP VCCKEEQIDA LSNNLKLADG IISSCPACKD NFFNIFCTFT
CSPDQSLFIN VTKTEAGSSG KDLVTELDNL WSEEYQSGFY DSCKNVKNGA SGGKAIDFIG
GGAKDYHQFL KFLGDKKFLG SPFQINYRTE PADDSQGMEA LPIHPKTCND ADPAYRCSCV
DCPDVCPELP EIKTEKQCHV GLIPCMSFSV ILIYSIFLLA IAGFSSYFTW KEHRYRKPER
VRLLQDPNPS DDEDEGDIVQ GAGHLEYPRG LYKLNSMLDA VFSRIGSVCA RFPALTIISS
VVVVVLLSLG WLRFSVETDP VRLWVSPTSA AAKEKEFFDE NFGPFYRAEQ AFLVNDNSSN
AGGRVLDYDT LSWWFGVESR VSRVISLDRG LSLDDVCYKP TGDACVIQSV TGYFGGSLAN
LKPDTWEERL THCTDSPGDV DCLPGFSQPL RPEMILGGYE STGNVLDAQA LIVTWVVNNH
AQGSEGEAKA MDWEDSFQRI LTVVQEEATT RGLRVSFTTE ASVEQELNKS SNTDAKIVVI
SYIIMFIYAS LALGSVTMTW RSLLNNPSNA LVQSKFTLGV VGIIIVLMSV SASVGLFSAA
GVKVTLIIAE VIPFLVLAVG VDNIFLIVHE FERLNVSHPD EEIDERISRA LGRIGPSIFL
SALTETVAFA LGVFVGMPAV RNFAVYAAGA VFINAILQVT MFISVLALNQ KRVESLRADC
IPCLTVRKAH SGMPEERAFE DQDGESALQK LIRKIYAPYL LNRRVKVIVI IVFLGILTAG
LALIPEVALG LDQRIALPSD SYLIDYFNDL SEYFGTGPPV YFVTRNVNIT ERQHQQQLCG
RFTTCEEYSL PFVLEQESKR PNVSYISGST ASWIDDFFYW LNPQQDCCYE DGKLCFEDRT
PAWNISLFGM PEGQEFIHYL GKWIDSPTDA SCPLGGKAPY SSALVFDPKR VMTNASHFRT
AHTALRTQDD FIKSYISARR IAQGISEEHG IDVFPYSKSY IFFDQYVSIV QVAGTLLGSA
VAIIFAITSI LLGSVATGAV VTATVIMIVV DIIGSMAIAG VSLNAVSLVN LVICVGIGVE
FCAHIARAFM FPSRSIMDNV PTKFRGKDAR AWTALVNVGG SVFSGITVTK LLGVCVLAFT
RSKIFEIYYF RVWLALIIFA ATHALIFLPV ALSYFGGESY ADPEASGGLE ENLASRGYRS
LLVDDDYDSD EY
//
