ID A0A1L9U056_9EURO Unreviewed; 1380 AA.
AC A0A1L9U056;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OJJ65049.1};
GN ORFNames=ASPSYDRAFT_142039 {ECO:0000313|EMBL:OJJ65049.1};
OS Aspergillus sydowii CBS 593.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036612 {ECO:0000313|EMBL:OJJ65049.1, ECO:0000313|Proteomes:UP000184356};
RN [1] {ECO:0000313|Proteomes:UP000184356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 593.65 {ECO:0000313|Proteomes:UP000184356};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV878582; OJJ65049.1; -; Genomic_DNA.
DR STRING; 1036612.A0A1L9U056; -.
DR VEuPathDB; FungiDB:ASPSYDRAFT_142039; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000184356; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR CDD; cd11741; TIN2_TBM; 1.
DR Gene3D; 1.20.58.1520; -; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF03999; MAP65_ASE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000184356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 9..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 725..858
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT REGION 81..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1116
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 153342 MW; 14AE035579939CDC CRC64;
MKSPSPEPAP ALFVRAMYDY DADDHTSLSF RRGDIIQVLN QLETGWWDGV INGNVRGWFP
SNYCAVVTDL RELEDHISHI QDDGDISADS GAGEEFEEHD DEVDSHGNPR DSQPILPIEG
MDPPTQQEEA AFWIPQATPD GRLFYFNTLT GYSTMELPFE NPSVNENSPY DRTNFFVPDQ
TRPPPELMAR GFERDEDDYD GSASEAEGES LMLASHDSMS RRRRSFIDGV SPATSMDSLQ
PLSATKSTGE GKSPLGRHPQ KLYGAAGADS NTSISEPMHR PSVSSAVSHR FIDDHTSTPI
TWPLLVDKMS QAVEVYRQTL LSGDRAEYVR KAEDISDHLR MLLAAGSDTT DNHSGNPSII
STNKPLYQHF RDMMSKFSKL VLSSHMAAAD WPGVDAINKC LQEADGVMQG VYGYVEVARQ
QRGEYIHRIV PGFVMGSSSG GSWQNNGVSL SESGPTSFLD QDGADLRPEP TVPLEPNVLD
HIDVLRRSFV GAIRRVEERL TLNQKKIVTV AEHEEIGELI AVAAVKVVEQ FRPWVSAVES
INLGPLGTSF QNPQLVDFSS QKQRGYDAIA DFVLSCQAVS APLGDEWAEL RGDSLDDRLN
AVRGVARQLE NYVSQIGFSL SLLLEQVPEP NSLRTESRAG DSEGYTGLHS RTESRSTEIG
VPSAHPLEGE KVRRNMDKAQ RFFGQAPPAA ITREPVQNLA REPEETPWFL KMDHEGEVFY
DTKNDIPTLK CGTLAGLVEH LTRHDKPDPS FNSTFLLTYR SFTSAAELFE MIMQRFNVQP
PFSLNADEMQ IWVDRKQKPI RFRVVNILKT WFENYWMEPN DESHMQLLER AHSFTKDSIA
TTKTPGSTQL LAVIEQRLRG LDTTVKRLVP TQATPAPTPI IPKNMKKLKF LDIDPTEFAR
QLTIIESRLY SKIRPTECLN KTWQKKVGPE EPEPAANVKA LILHSNQLTN WVAEMILNQG
DVKKRAEIAR LETLKEQRAP TLQLIDRHRS LLAEREALNA SSQDASRLMA RGNKGERRDP
GKLLREEKMR KRIAKELPKV ESDLRKELEN FEDEYGRPFL VHGESYLDEL TKVAAKPPPR
SKTPSAAPSS ATKRNAPPSR PGSVMRGPPP PRSSTKTPTG GQPTKYNTIG PSRSGAKSPT
KIPGRVPLGN MPHGNNSPDR RGPGTYSSST VNGKMSSSRA PPPRMRALTA TDNKDERPGS
SLFESPRCAS ALSNSFVRPV SPEDVYDDRQ RSFMSSSIFS QRSTGFSQSS QSSHSSGSLK
SSLQGHYPRP NPYLQHALPP PAPRQVSSTS TADTVTTGSE NWETFDDASE SDSETSDAYY
AKLRAAHGKR LAPEDHHQPI SLAGKKAKGI RSVSPDEPIG RHMVRVADSD NGWTDDMETY
//
