ID A0A1L9U6S6_ASPBC Unreviewed; 808 AA.
AC A0A1L9U6S6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN ORFNames=ASPBRDRAFT_68995 {ECO:0000313|EMBL:OJJ67332.1};
OS Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767769 {ECO:0000313|EMBL:OJJ67332.1, ECO:0000313|Proteomes:UP000184499};
RN [1] {ECO:0000313|Proteomes:UP000184499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101740 / IMI 381727 / IBT 21946
RC {ECO:0000313|Proteomes:UP000184499};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
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DR EMBL; KV878694; OJJ67332.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9U6S6; -.
DR STRING; 767769.A0A1L9U6S6; -.
DR VEuPathDB; FungiDB:ASPBRDRAFT_68995; -.
DR OMA; AGGKQQN; -.
DR OrthoDB; 11387at2759; -.
DR Proteomes; UP000184499; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07751; PolyPPase_VTC4_like; 1.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184499};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 697..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..172
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 94..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 343..370
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 94..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 92819 MW; 3F7D53AF69856E68 CRC64;
MRFGEHLRSS MIKEYYWYYI AYEDLKNALK TGYVTEPTPE NARPDRQPWS EDDEKHFVTL
LESELDKVFN FQRIKSAEIA RRIQASETEV NDVVSRLDNS SSSRSESASN SRSSRKPPSD
EDFLLLEQVL SDIIADVHDL AKFTQLNYTG FQKIIKKHDK QTGWHLRPVF AARLNAKPFF
NDNYDALVVK LSKLYDLVRT KGNPVKGDSA AGGSQQNFVR QTTKYWVHPD NITELKLIIL
KHLPVLVFNP RKEFEEKDAA ISSIYYDNTD TWELYQGRLK KTEGAEAIRL RWYGGMESDQ
IFVERKTHRE DWTGEKSVKA RFSLKEKHVN AYLSGRMTVE SIFEKMRREG KKSEEEIDNL
EQLAREIQYR VITRKLVPVT RSFYHRTAFQ LPGDARVRIS LDTELTMTRE DNLDGRSRAG
DNWRRMDIGV DWPFSQLPPE DVERFPYAVL EVKLQTQAGQ EPPQWIRDLT ASHLVEAVPK
YSKFIHGTAT LFPDRINLLP FWMPQMDVDI RKPATRKFGI QRPPASAPLS TTETPEDDES
DEEDSNEARW VESTNRAQAT TADQEALFAD TDGNALDIEE RIAAQPLPGD EDYPLYDSDA
ESVDSDELEE ARRVGGTYYY KQLAKYYAHN AGHAMVNCFI ALIPRPRPTS MPPPEQNGIS
VMGNKRTVKR FQAPKGKRIH VPVRVEPKVY FAAERTFLSW LEFSILLGTI AATLLNFGED
YITFGSSWAF TVLAAVALLY SLMLYVWRVD KIRKRRDVKR VYYEKWGPTV VGLGLVVIVM
VNFGLRARQA GFLAKDGDLD DAPHGGEL
//
