ID A0A1L9U779_ASPBC Unreviewed; 730 AA.
AC A0A1L9U779;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Geranylgeranyl pyrophosphate synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPBRDRAFT_135175 {ECO:0000313|EMBL:OJJ67547.1};
OS Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767769 {ECO:0000313|EMBL:OJJ67547.1, ECO:0000313|Proteomes:UP000184499};
RN [1] {ECO:0000313|Proteomes:UP000184499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101740 / IMI 381727 / IBT 21946
RC {ECO:0000313|Proteomes:UP000184499};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
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DR EMBL; KV878693; OJJ67547.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9U779; -.
DR STRING; 767769.A0A1L9U779; -.
DR VEuPathDB; FungiDB:ASPBRDRAFT_135175; -.
DR OMA; IDNEHEF; -.
DR OrthoDB; 5770at2759; -.
DR Proteomes; UP000184499; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0046165; P:alcohol biosynthetic process; IEA:UniProt.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR GO; GO:0043386; P:mycotoxin biosynthetic process; IEA:UniProt.
DR CDD; cd00867; Trans_IPPS; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 2.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001:SF72; THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR Pfam; PF19086; Terpene_syn_C_2; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000184499};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..390
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 81778 MW; 2B6F27174869D57F CRC64;
MFKQYSHILS HKRRRSRGST INQVLSGAQS EPASEAATVT EQPVEVWTHS QVLPEDDEHR
KDCFTTLTPR IHKYDHVAQR GSDRFVQDLT AALNLDEPQT SYLSSPVGNY ASFLYPECLP
ERLETVAYLT ELGNLHDGKQ QGKKTDESAE SPRVAARKEL LEKAMSELSD KDKDGHEIID
CYRSNWLVTP EVPTAENCAN LDDYVARRRL NAGIDVYWTL MGFAHGTRLG KEDQAVVRDA
LDAAERTMFF TNDYYSWPKE KRVSKKRPVA NVILFLMEHQ NMSEEDAVAK AKQLIIDNEH
EFVRRREALY QANADLAPQL RKWMEVLGAS LAGIHYWCKN APRYAVPETA EESEEDEEES
SSEEDGSEEE SSSEEDTEDD DEEEEEGEEK AAPVEVVPEP EESEEPVEVA VWTPLVTEEE
TPDVHLDTSA LLAPSSYARS ISRSTLHSDL LTSLNAWLQV PARPLAFIRQ VVTELQDSTG
MLADVQDQAA LRDQRTPAHL VYGPAQCMNS AAYLFVRAAR IVTSLNCPGM LDALLQELEA
HFVGQSWELN WRFSTHCPGE TEYLAMVDQK AGASFRLLTR LMQAASMGGA TLDLDPFTKV
LGRLSQIRHE YLGLLESATN ERSFGEDLDQ AKVTYPIVRA CNLDPAGRAV IFGIFRQKPA
GTVLPIESKR QIVSLVQQTG ALQATYDLIR QLGREAMNTL SELETAAEEL NPSLRAVVKS
LVEVPAPEHL
//
