ID A0A1L9UMP5_ASPBC Unreviewed; 1011 AA.
AC A0A1L9UMP5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=von Willebrand and RING finger domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPBRDRAFT_123415 {ECO:0000313|EMBL:OJJ72967.1};
OS Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767769 {ECO:0000313|EMBL:OJJ72967.1, ECO:0000313|Proteomes:UP000184499};
RN [1] {ECO:0000313|Proteomes:UP000184499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101740 / IMI 381727 / IBT 21946
RC {ECO:0000313|Proteomes:UP000184499};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV878683; OJJ72967.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9UMP5; -.
DR STRING; 767769.A0A1L9UMP5; -.
DR VEuPathDB; FungiDB:ASPBRDRAFT_123415; -.
DR OMA; SEAHWAQ; -.
DR OrthoDB; 663280at2759; -.
DR Proteomes; UP000184499; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd16448; RING-H2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000184499};
KW Transferase {ECO:0000256|ARBA:ARBA00022676};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 23..69
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 496..669
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 99..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..828
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 111601 MW; C78B068813EDA884 CRC64;
MAGLMDVDRT RTRRDRTFVG TECAICDEPL EHTLRGERVL QFSCTHVSHE ACFYEYIREF
EGQYCPTCDA PLGLDTSRGG NMLDLEKLSN IVRSVTSDAA THRSGMSNLP PWEPVPVQAR
RPSDAGSHAG SRPHNRDSRD TYVRRDSRDN SSHRERVERL TMGSRQHHSR NGSVAGSSDY
NESHQHAANG RRHDYDVQAM ESDLSPRPAV TKNPIPAPTV TIRSEFPTLN RSRQQQSLTC
LITVEVPEGS WQPDASDLTA NGKDQPQDEP YGAMRFPPNQ EPKPIPYENQ ENLDDLAEDL
RNKVDNWHGL EFNRFGKLRL HGHMSVGKDR TSWQELECYL FGEMLICVKE KKTTQRRSYD
DDQSKPKPTR CTLKGSILIK KHLNSMEAAT DEPILALNLS VSELPCFYLR FPNRSQLELW
RRSLLDLHPM ESASPNNDYD YDNSGAEEED YRNNQIKRQA SINSSYGAAR SINTAITDYT
NMGTESPAPS IHIPLDLVVV IPVSSSMQGL KITLLRDALR FLVQSLGPRD RMGLVTFGSS
SGGVPIVGMT TKSWGGWPKI LESIRPVGQK SLRADVVEGA NVAMDLLMQR KSSNPISTIL
LISDTSTSDP DSVDFVVSRA EAAKVNIHSF GLGLTHKPDT IIELSTRTKG SYVYVKDWMM
LRECVAGCLG ALQTTSHQNV KLKLRLPEGS PAKFVKISGA LHTTKRATGR DAEAALGDLR
FGDKRDVLVQ LVIPPDNSTQ DLTPQDAWES LVSGLEALGG MSDGDDQRVA SVEEVPLIQA
DLTYGDFLRE GHLTHSPRPS LLAITMLPPN PKAKPGRPSS PPIPPHPSIV QRRMELLTSD
MLTRALTLVS RGQHDRAQHL LTETRSILKG LGKGGLPPLP PGARPAGTSD SGSRADTPTS
SSPKSSMFDG HSSAASDTAT ITSVSAVDGQ TMTALDADLQ SALEWINHPA VFSRDSRKAV
LQGIGVISSQ RAYTFRSPSE AHWAQRVAGV RRLTERSKEW RETGDDALTE E
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