ID A0A1L9UWA3_ASPBC Unreviewed; 1672 AA.
AC A0A1L9UWA3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPBRDRAFT_192166 {ECO:0000313|EMBL:OJJ75988.1};
OS Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767769 {ECO:0000313|EMBL:OJJ75988.1, ECO:0000313|Proteomes:UP000184499};
RN [1] {ECO:0000313|Proteomes:UP000184499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101740 / IMI 381727 / IBT 21946
RC {ECO:0000313|Proteomes:UP000184499};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV878680; OJJ75988.1; -; Genomic_DNA.
DR STRING; 767769.A0A1L9UWA3; -.
DR VEuPathDB; FungiDB:ASPBRDRAFT_192166; -.
DR OMA; ICNYATM; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000184499; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000184499}.
FT DOMAIN 378..503
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1426..1669
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1672 AA; 184207 MW; FF710CFD05DF8237 CRC64;
MALSSTSVDR FPSEPGQPQP DTFLTRINPG TQAKVLASAD SQYATTDLRR AHTVAHGRNT
KETPTIGSRS TRGRLATSLL RVKDSHEILR KRSFKRPDTS QAPSDAAVGA REPNHFTVGN
VGQNGKIFLR PIRNPPTKEP FPAPSIPSPS QSRQEHFSHG RGGLESDEPS RWSNSQLSEL
RPELIPEESC EDGDSINTES ARSQYHGLPH HRPRKAHSFS TISEQRSESR AGRAGELRIY
IDRADNRPKT ANEPSQRALE VSIPRYRLDL PQSSLDNETA LHSSIYSRTS LSDIMRTSRL
PREYWVGTLA SDSYLRNLER PSFVGSVFSG AGAIELPRSS AVSENPVFYE LKEPIEPAIF
ETLVSEMDKE SVVRYASGTR DISAATPARI VAQISSASFM DYELVSDFFL TFRSYISTGT
LLALLLARLR WAINRLQDDG RIIRIRTFAA LRHWILNYFV DDFVPEYDLR AHFCETINSM
YDDVKSRQGG GMSDLKILID LKRCWYGKSS LYWNFPNDHD VFQSPDVAIL PGDREADALE
MVAGGDLLAL VRTRSGLEAG PAGTEYRPNH HSRNNSSNTV KSVPISAGSD RSFQAISCSL
PPKSPKRLSL SLANKAPHPV PLMPLKPTSS REAYPPSPLT SRRYPYPGHS HKRSGSFSDS
VRDDRAPFSL LNLEQQGVVA GREALDLSSL IRGELYPPAE SYTIMMAPPS PPLPSSAKDM
ALDRRSTTHG IHKPAASSSG VKTIIGSIRR ALNSRHGGQG SFSRAMNGPA NPSLMGRTSA
LPNNVAFGSD AYKGRKTAAG VKKPTRIDTL CDEVLKQYRA AISEQTDTKA GSQSADSQNH
GDHHSTAPGQ PRATSQVTAG SESIVIVDGT GLGIPVMSGA IGEANTGLQQ PPGFLEAEPS
PATVRAPSPY APHQRSTLAT DEYSLPIFYD EPDPGPSNRA SKFLRPSGFS ESSRRSYSVE
RGSSSWKRTS SSLRLRKYAS FQSGVSKHRL TMGSDSVPPL PPGSSQQHLD KPSGPTLRRR
PGGDLRQMRN GGGSQSRPDS GSFVSDITYR SSGADTAVTR VEEPYSRPQT SLIPPNPRFS
LLTTHSSQNL RRSFEDAIAQ FAQIPDDDDG GIESTLLKLE GKWQGASSGD AEASAAGPSQ
YREHYDPGEV TGEEWFRRSR GSAGHNFANS DAVARRRQTF YGDGLTYSQV QGRVVPQRPY
SDSIAESEDS YSSIPLLERG LSDESMKKPV ESRRTSHMAG PSRFQPSFSS RETSDMESSH
PSIDIVKETE SMKRIPRGST LPSNAPGSKK HTGRLSGLSS GISIDMIDSR EAAEQRFSLD
THSMSDSSLG IPPHPLAHPP SPPMTVQNTR SVGSWTTPLN PVLFQAQPLT PDPSPRNKMA
QQANIRPVNT QQVSGDVLSQ SEKGRRFPEP LKIAGPEHVP FVLSCESHVL AQQLTLVEMA
ALSEVDWRDL VDMRWSSGSP TMLNWVQFLM EDEHRGIDLV VGRFNLMVRW VLSEIVLTQD
IHERARTIGK FIHTAAHARR MCNYATMLQI AIALSSTDCS RLQATWALVP VADKRLLKDM
ESLTQPIRNF HELRLEMEMA NAQDGCIPFV GLYVHDLTYN AQKPARVTTQ DGESLINFER
YRTTAKIVKS LLRLIDASTR YRFEPVPGII ERCLWIASLS EEQVQLRSKQ LE
//
