ID A0A1L9VA01_ASPGL Unreviewed; 1148 AA.
AC A0A1L9VA01;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN ORFNames=ASPGLDRAFT_51146 {ECO:0000313|EMBL:OJJ80730.1};
OS Aspergillus glaucus CBS 516.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Aspergillus.
OX NCBI_TaxID=1160497 {ECO:0000313|EMBL:OJJ80730.1, ECO:0000313|Proteomes:UP000184300};
RN [1] {ECO:0000313|Proteomes:UP000184300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 516.65 {ECO:0000313|Proteomes:UP000184300};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KV878909; OJJ80730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9VA01; -.
DR STRING; 1160497.A0A1L9VA01; -.
DR VEuPathDB; FungiDB:ASPGLDRAFT_51146; -.
DR OrthoDB; 276824at2759; -.
DR Proteomes; UP000184300; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 3.
DR Gene3D; 4.10.80.160; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 2.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 2.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000184300}.
FT DOMAIN 483..673
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 688..896
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 180..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..963
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1148 AA; 130091 MW; 08B16443188A978F CRC64;
MERQRKRELR SLNERAWAGE SDIFSVSKSL DSALKKNTAF IKRLRTGISA STQKTFLADI
RTLSLHKYLS EIISACYEGL CKLKSPGEIA VGVEIASALH QRFGPAEFTR QIGWLLGRGL
STPDKSQLKA LAPELREKEE KERLSRHRIL LRVVTELWLV GVLRTLDDIE RPEDLGAKGK
DGVVGKTPDT VARGKPSADK EADPFPLEVL KDLLGHDRQH ANLPLAVLFV KSFGWDILGV
KGVEEGRKTV EADGATTVEA TESNQNGTDA SANENDLPLT PEKTQNRFKA ILNRYLEDVK
AHVVRDQRAL ATQSRRNAEA YVKSGEIFED RQATFDKQSK NLEKLVSNTQ VLCEALGVEM
PSLTEQETAD QASSGGIGLV RTAEYLRGQG EGAGIWEDEE ERRFYENLVD LKGKVPAVLL
EDGKKKKADD ESAKKKVDGE TDPSAETKGE STGQAQSPSE EKPPSEADDQ SAAMVSKTVG
AQVDALLAKL PDLQNKDQVD QMALDFCFLN SKASRNRLIK AVSDIPKGRV DLMALYARLV
ATLGQHLHDI PQGLITYLDE EFRSLQRRKS KEFLGQVRMS NIRYLAELTK FGVVPEHIIF
HCFKVSLDDF SRMNIEIIGH LLENCGRYLL RNPETSPRMA SFLETLSRKK TVQHLGQQER
MIIENAIYYV DPPERPAIQQ KERTPIESYI RRLIYMDMNK RNYTRILKSI RKLHWEEQDV
VNILERIFSK PVKVRYGNIH LLAILVSALY RYHQDFVIGI VDNTLEYITL GLEQNEFKFN
QKRIAEVKYL GELYNYKMID SPVVFDTLYR IVTYGHEGGT PIPGKINPLD LPDDFFRIRL
VCTILDTCGH CFDRGSAKKK LDFFLTFFQY YIFTKEPLPM DVDFLIHDTY SATRPQWKLA
GDLQEATIIF SEAVAQNYKT QDAGKHMEPE PEEEDVETSS SDEGLEEDAM PEVEDEQESS
DEAEAEASGP NAEQNDDSES DDEAFVGRQE EERDPEVEAE FDRELEKMMA DSVDSRRFER
KAVFDVPLPM KRAAREASGA EHTESSQDQA NTMAFSLMTK KGNKQQTRTI DLPSDSSFAL
AMKSQQQADR EEQQRIKNLV LNYEMSNEPE NTEVVEKRTP PRDTRIDKSA ANRSAFRSRK
LQLSDVNW
//
