ID A0A1L9VBY0_ASPGL Unreviewed; 2533 AA.
AC A0A1L9VBY0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN ORFNames=ASPGLDRAFT_76379 {ECO:0000313|EMBL:OJJ81437.1};
OS Aspergillus glaucus CBS 516.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Aspergillus.
OX NCBI_TaxID=1160497 {ECO:0000313|EMBL:OJJ81437.1, ECO:0000313|Proteomes:UP000184300};
RN [1] {ECO:0000313|Proteomes:UP000184300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 516.65 {ECO:0000313|Proteomes:UP000184300};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; KV878906; OJJ81437.1; -; Genomic_DNA.
DR STRING; 1160497.A0A1L9VBY0; -.
DR VEuPathDB; FungiDB:ASPGLDRAFT_76379; -.
DR OrthoDB; 1830977at2759; -.
DR Proteomes; UP000184300; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0005643; C:nuclear pore; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR021827; Nup186/Nup192/Nup205.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR Pfam; PF11894; Nup192; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000184300};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 2163..2406
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1657..1774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1660..1680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2533 AA; 283986 MW; 747409578084EAA9 CRC64;
MEERESLVGL RGLYQDLSAL SDSSLVNIDR LRVELETHID DFRKLLDKPM KNNASRQAIM
SGKITVDDVE YSVNQEFQQG VLELADSINI DELQAAKMFL VAQEEAQLLD RPPLIAAIMR
FHERRLFLLE ALRLVFQESS FEVEKEMTQE LMQEVVAHVL EIKGAPLRNA SLYARKAMGS
MEDIEKTLIL LGEQIQKASI VGQAGDPDVM EAIEYQRNSL QQQHESLGAI LCYMFKGPYT
SPEEIRHLLN RLRKLDRFDG LLVHYIPSII SSFVKHGSPE SAASYKEARS LHTAITSSSK
DGQAWILPTF HSAVIALWLA VYSGWDYDGP SSPLPGVDLE KEAQERTKMF MTALDDGGLD
FILAVCSGVN NEEQGDPARG ELVTLLLKES TAAMPESDSC SEYLKKLLME NLEVFVESCV
ANMPDAVRML KTEEDTQRLD QITALRDGLT SSLHRGLVEA RTHLESFLMV IAFAFDNRPD
AAQEFWADQD GNLYGFLQWA SKRQTVPRVS AFCELLCSIA GGEENATAAH RFLSEEDKFM
SGKFRRSTSM NWSQMFAELQ LYASRVTEKP PTTSQAILRA RKPESADMSE PESPVMLTCY
LRLMGHLSKQ SATIREWMLH HPSFNLVSTL LTLCSGPIPT HLRATTFKTL AALMTDRSTI
NGHEMWLSLD QWISGGSMGA SGLSKAPMVS NPLVWHEQQA FQKISESFNQ ANAFVDLIHT
LVSPTLDTAG NPLSLSFPES LGSSYRMPGI EPYVDLVLGQ ALSRKVPDLN EQQARLLTYN
CLDFALTCLR SFNENLVTVL SQPTVASDSA LKTSSLVAYI RLHPFARVAE WLFNEEVLKA
IFATAHQDIM EVSRAPSEST LVLGLLRSLE VMDEMMELQS TYLNIVRPLI RSQAEGSRLN
VANSALSSFE DSILNNLTIV PALCLYCGTG HEQLTVTSMG LLEKMSSSKR LNKLSSPELS
KWRPSNKIVE VLSAEVDVDS VSRPLVTHMQ LELRELESGS QSAGYVIREG LLALLNTCLG
MITDRPTVAH LLLGFNSVGN MLDVTPDGLF ANQMSLLHAV IGFLESNPDE VDGNILPWMV
HLKCMALEVL KHLWSSKLAA FFTLSEMRSN QFLVNMFASQ PIIGTNTMWN GFPIVTEEFW
LSDSASALAE FLLYRSFLYN YAATEIRSAA KLGSPTLQTE IISTLLGTSR VETGETVPHV
TVFDLFDFAD LDIAHQLSPP NLIFLDGLDL EVCAKPQADE SLVLYDVAEI EELIQVRKED
LLDNGQFRPQ DEELFLVEAG NLTLFVQSTN KNKQIGHNRY LTLRSWTELI TTMVTYSNID
GGRRPTFILH SIQMILPKLE TAVEEDLPEA IELARLAETL ISNLELTTSN AKSTRSGDII
DDKLHQLFQI CIRGIILATG NVSLRETFYN ICSHYITRIA SPDPAHENLR RHSQQVVKTA
GLALIEATCD DAYSGQETCR VSALLLLNLL ATLDNQVDSI LAESISQSNY LALFLDAIRA
LPIELRNAQA SDTPLLLSFY QSLLSLLQQL CQTKNGAIHV IKTGLFDAVR ESQLFAADPD
IGIDIDNPDA LRKYYDLLLA VLRVIVSAVF VRGLHNEQIM EQTRAFLAEN RQSMIGIFKR
FAKIGGAGSA DHQETISDLT KSYMALVAAT GFLDNSRGAT EQRTGKRKSI GKRKNSEEES
SSSSQRQQPQ HPPPQQQQTI SELLSRNQDR GHPPYLSPKR ARLSPTPSDS SSSTRPQALR
SPSSMYNFSN SDSRAGGAFG QSSSASNPTA NAGPAFATAR QSNFTPHTGA RKLSIKNLRT
TPRLNQDSYF EKVWGQLDTA LGAVFGGGKP ETSLEELYKG AENVCRHGKA AALAKKLQDR
CREHVLGKLR ETLVAKAGGG SDIDTLRAVV DTWETWQSEL VTVRWMFYYL DQSFLLHSKE
FPVIRKMGLL QFRSHIFSDA ILKPKILQGA CDLVGADRSE GNNTMADSSL LRNATDLFHG
LDVYISDFEP LLVSQSKEYF SLWTQQETTG YLATFVENSH RLIEREVNRC ELFSLSRSTK
QKLSEILDGV LLSQEDFLLD KKDILGLLRA SNKTALEKLY ALLERKDIGG WLKPAFGSYI
VEEGSGIVAD EDKEGEMVPR LLEFKRQLDD TWTDSFHRHE ELGHTLRESF DAFMNKDSKM
ETKMGEMIAK HVDRLLKGGW KLPTGRKPED MPLADEDAEI NRQLDQVLDL FRFVHGKLVF
ETFYKNDLAR RLLMGRSASD DAEKSMLTKL RTECGSSFTH NLESMFKDMD VARDEMAGYS
SIQRERRHRL QVDLNVNVLS ASSWPTYSDV QVRIPPVVAT AINDFEQFYH NKYNGRKLHW
KHQLAHCQLR ARFPKGVKEL VVSSSQAIVL LLFNDVPEGG TLQYSQIQEE TLLSDVELQR
TLQSLACAKY RVLSKRPKGR DVNPTDEFAF NDAFTDPKMR IKINQIQLKE TKEENKTTHE
RVAVDRHMET QAAIVRIMKS RKTITHAELV AEVIKATRSR GMLEVSEIKE NIEKLIEKDY
MEREEGNRYQ YVA
//
