ID A0A1M2W7G0_TRAPU Unreviewed; 404 AA.
AC A0A1M2W7G0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Tethering factor for nuclear proteasome STS1 {ECO:0000256|RuleBase:RU368013};
GN ORFNames=TRAPUB_3894 {ECO:0000313|EMBL:OJT15788.1};
OS Trametes pubescens (White-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Trametes.
OX NCBI_TaxID=154538 {ECO:0000313|EMBL:OJT15788.1, ECO:0000313|Proteomes:UP000184267};
RN [1] {ECO:0000313|EMBL:OJT15788.1, ECO:0000313|Proteomes:UP000184267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FBCC735 {ECO:0000313|EMBL:OJT15788.1,
RC ECO:0000313|Proteomes:UP000184267};
RA Makela M.R., Granchi Z., Peng M., De Vries R.P., Grigoriev I., Riley R.,
RA Hilden K.;
RT "Genome sequence of the basidiomycete white-rot fungus Trametes
RT pubescens.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC turnover of proteasome substrates. Targets proteasomes to the nucleus
CC and facilitates the degradation of nuclear proteins.
CC {ECO:0000256|RuleBase:RU368013}.
CC -!- SUBUNIT: Binds the proteasome. {ECO:0000256|RuleBase:RU368013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368013}.
CC Nucleus {ECO:0000256|RuleBase:RU368013}.
CC -!- SIMILARITY: Belongs to the cut8/STS1 family.
CC {ECO:0000256|ARBA:ARBA00006199, ECO:0000256|RuleBase:RU368013}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJT15788.1}.
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DR EMBL; MNAD01000133; OJT15788.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M2W7G0; -.
DR STRING; 154538.A0A1M2W7G0; -.
DR OMA; KDAYPYS; -.
DR OrthoDB; 1704120at2759; -.
DR Proteomes; UP000184267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:UniProtKB-UniRule.
DR GO; GO:0031144; P:proteasome localization; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1590; Tethering factor for nuclear proteasome Cut8/Sts1; 1.
DR InterPro; IPR013868; Cut8/Sts1_fam.
DR InterPro; IPR038422; Cut8/Sts1_sf.
DR PANTHER; PTHR28032; FI02826P; 1.
DR PANTHER; PTHR28032:SF1; FI02826P; 1.
DR Pfam; PF08559; Cut8; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU368013};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368013};
KW Protein transport {ECO:0000256|RuleBase:RU368013};
KW Reference proteome {ECO:0000313|Proteomes:UP000184267};
KW Transport {ECO:0000256|RuleBase:RU368013}.
FT REGION 51..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 43686 MW; E9297584AC3D8523 CRC64;
MANVVTHPHL QVGFNPRPVG HSPTPIGFGF GLSATPVVQG WPSASHAQAF QWATHQQPPQ
PQLRVAKRRH EPEEGDRDDA MERSPTPERV RRSIPKRART TPTLVTVGKE PQGSKESKPA
ADDNDVDVGF LLASLPPQSL LPLLSSLLAA QPSLKPTILS LIPRPTLDAA LESLSISAQK
LKDAYPYSNS AFAQPGAAWG GTGGFGGRTG TASFNTGFGF GSRTGAGSSF GATTNAPGGM
RDEYILSRIQ PHIQDFVSAC LSYLPYFSNA TPDATSSPRP HAAQSHATAL RQQHKDKLHP
TETYMFLAAL TSHILSQPAL TQTTLVPMLA PRLAVEWKAW VDHVDASVNM QGGMYGRDTV
QTWERGLDEF AQAKGNEMAV MKEVRDRWVS KVGWLVGRQS MEGM
//
