ID   A0A1M3HKG4_9SPHI        Unreviewed;       741 AA.
AC   A0A1M3HKG4;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:OJW58835.1};
GN   ORFNames=BGO55_19130 {ECO:0000313|EMBL:OJW58835.1};
OS   Sphingobacteriales bacterium 50-39.
OC   Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales.
OX   NCBI_TaxID=1895841 {ECO:0000313|EMBL:OJW58835.1, ECO:0000313|Proteomes:UP000184242};
RN   [1] {ECO:0000313|EMBL:OJW58835.1, ECO:0000313|Proteomes:UP000184242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=50-39 {ECO:0000313|EMBL:OJW58835.1};
RA   Kantor R.S., Huddy R.J., Iyer R., Thomas B.C., Brown C.T., Anantharaman K.,
RA   Tringe S., Hettich R.L., Harrison S.T., Banfield J.F.;
RT   "Genome-resolved meta-omics ties microbial dynamics to process performance
RT   in biotechnology for thiocyanate degradation.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OJW58835.1}.
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DR   EMBL; MKTZ01000008; OJW58835.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M3HKG4; -.
DR   STRING; 1895841.BGO55_19130; -.
DR   Proteomes; UP000184242; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR017790; Penicillin-binding_protein_2.
DR   InterPro; IPR003124; WH2_dom.
DR   NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   PROSITE; PS51082; WH2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          668..685
FT                   /note="WH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51082"
FT   REGION          684..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..731
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   741 AA;  82194 MW;  8A869ABDAE16570A CRC64;
     MPVFNQSRSN IIRLIFAGMF LIIAAQLFHL QIVSKKYQQQ AQENALFRKS IYPSRGIIYD
     RKGRAILNNT ILYDLMVTPG QVKNIDTAYL CQLVGIDTTE FRHRVLDARI KNGPFRPTIF
     EDLLPPDMYA RLEENIWKFP GFNLQERPIR VYPFNAAAHI MGYVGEVDSS ILRRSNNFYQ
     LGDYVGRSGL EQYYEKALMG QRGIEFWIKD NKNRLVNHYQ DKSLDTPAIA GKNLRTYLDI
     DLQQLAERLL SGKTGAIVAL EPSTGGILAM ASGPNYDPNS LTGPDKQTNY ARLALDVSSP
     MLNRAIKGQY PAGSTYKPIG ALIGLDEGVI TPASGISCLG AYLACTKPVK CDEKVPGHAA
     NLRLAIAHSC NSFFCNTFRL TIDNPEYRST RKGLMKWKEY VNAFGLGHRI GVDLPSEDGG
     NIPDTTAYDK DYNRNWNSCS MVTLGIGQDK MNVTPLQMAN AMCIVANKGY YYTPHFVKSI
     DDAQGADSIL SKYHVKHEPV THISDDVFNV VQSGMQDVIE IGTGRPARIP GITMCGKTGT
     AENKQRIDGR TLKLHNHSWF VCFAPRENPK IAVAVIVENG GYGGTWAAPI ASMIVEKYLN
     DTLRNERLPE VNRIAGSNMM PKYLVRVQFR TDSMRAADYA NQTGDSARLL KYIDKANRAM
     LLDTVDGSRS PLLAAIRKMP NLKPLTPRVT AAPTPAAPAQ KPDSGGHVPA LDTSAIHAVR
     HKAKADTVQK PLDQKGDSTQ R
//