ID   A0A1M4MYI5_9RHOB        Unreviewed;       493 AA.
AC   A0A1M4MYI5;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Mannitol 2-dehydrogenase {ECO:0000313|EMBL:SCM67650.1};
DE            EC=1.1.1.67 {ECO:0000313|EMBL:SCM67650.1};
GN   Name=mtlK {ECO:0000313|EMBL:SCM67650.1};
GN   ORFNames=KARMA_1852 {ECO:0000313|EMBL:SCM67650.1};
OS   Donghicola eburneus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Donghicola.
OX   NCBI_TaxID=393278 {ECO:0000313|EMBL:SCM67650.1, ECO:0000313|Proteomes:UP000184085};
RN   [1] {ECO:0000313|Proteomes:UP000184085}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wibberg D.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FMJB01000047; SCM67650.1; -; Genomic_DNA.
DR   RefSeq; WP_072706293.1; NZ_FOXY01000001.1.
DR   AlphaFoldDB; A0A1M4MYI5; -.
DR   Proteomes; UP000184085; Unassembled WGS sequence.
DR   GO; GO:0050086; F:mannitol 2-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023027; Mannitol_DH_CS.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43362:SF1; MANNITOL DEHYDROGENASE 2-RELATED; 1.
DR   PANTHER; PTHR43362; MANNITOL DEHYDROGENASE DSF1-RELATED; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:SCM67650.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184085}.
FT   DOMAIN          30..191
FT                   /note="Mannitol dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01232"
FT   DOMAIN          220..464
FT                   /note="Mannitol dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08125"
SQ   SEQUENCE   493 AA;  53673 MW;  1201F4E2905CC985 CRC64;
     MATPLSLNTL DQLPETIGKP SYARSDLSGG ILHFGVGNFH RAHQATYLHQ LFNQGKGHDW
     AIVGAGVMEG DKRARDVLAA QDWLTTLVEQ EKDSSGAQII GSMVDYLEPA NAQAIIAKLA
     DPAIRIVSTT ITEGGYFLDA TDTFDPTHPA IAHDGENPDT PKTVFGMIVA GLKARRDAGH
     APFTIMCCDN IPHNGNVTRN AVVGTARLSD RDFADWIVTN VAFPNSMVDR ITPATSDRER
     QIAADEYGVQ DGWPVFCEGF IQWVMEDNFP LGRPELEAVG VEFVEDVAPF ELMKLRILNG
     GHAAIAYPGG LLDIHFVHEA MEHPLINAYL AKLTAEEFLP GVPPVPNTDT SEYQKLIDRR
     FSNPKIGDTI RRLCLDGSNR QPKFIVPQIR DALARGGSIT GLALESALWC RYCYGTSESG
     AVIEPNDPNW DMLVATSAKA KDDPQTWLTG LPAVYGDLAQ NEAFSTAFAA ALNALWTDGT
     AAVLTKYLED QPL
//