ID A0A1M4N3B2_9RHOB Unreviewed; 882 AA.
AC A0A1M4N3B2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:SCM69380.1};
GN ORFNames=KARMA_3618 {ECO:0000313|EMBL:SCM69380.1};
OS Donghicola eburneus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Donghicola.
OX NCBI_TaxID=393278 {ECO:0000313|EMBL:SCM69380.1, ECO:0000313|Proteomes:UP000184085};
RN [1] {ECO:0000313|Proteomes:UP000184085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wibberg D.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FMJB01000064; SCM69380.1; -; Genomic_DNA.
DR RefSeq; WP_072708913.1; NZ_FOXY01000004.1.
DR AlphaFoldDB; A0A1M4N3B2; -.
DR Proteomes; UP000184085; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000184085}.
FT DOMAIN 704..720
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 630..637
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 882 AA; 96327 MW; E39C3082AF8B8EDB CRC64;
MAATGVTPMM AQYLEIKEAH PGSLLFYRMG DFYELFFDDA VAAAEALDIA LTKRGKHEGD
DIPMCGVPVH AAEGYLLTLI RKGFRVAVCE QMEDPAEAKK RGSKSVVKRG VVRLVTPGTL
TEDSLLEARR HNYLAALTEV RGEVALAYSD ISTGELRVVS LPEVRIGPEL ARLMPREVLL
SDNKEEDWAE LIEDNGAALT PLSRAAFDST AAEGRLCKLY KVDTLDAFGS FTRAELSALG
AIVEYLDITQ KGTLPLLRAP VREAQDRVVQ IDASTRRNLE LTRSLSGGRQ GSLLSVVDRT
VTAGGGRLLE RRLSAPSRVL DEVQRRQEAV AYAVDHTITA NQWRESLRRV PDLDRALSRL
SLDRAGPRDL TAVRNTITQS LDLAETLSQL DLPPLLSQLT VDMAQQEELL DLLDQALIAE
PPLLARDGGF IAAGFHAELD EARTLRDEGR GVVAGLQAQY AEETGISSLK VKHNNVLGYF
IECTATHGEK MLGMGERFIH RQTTANALRF TTVELSDLET RILNAGGRAL EIEKRLFEDL
RQAILEQAAP LGSMARALAE LDLTTALADL ARSEDWCRPV IDDSRTFRID AGRHPVVEAA
LKSDGDPFVA NDCELSPSPR DGAAIWLLTG PNMAGKSTFL RQNALIALLA QMGGFVPAQS
AHIGLVSQIF SRVGASDDLA RGRSTFMVEM VETAAILNQA DDRALVILDE IGRGTATYDG
LSIAWATMEH LHDVNRCRAL FATHYHEMTA LTEKLNGVEN ATVSVKEWEG EVIFLHEVKR
GAADRSYGVQ VARLAGLPTS VVERARVVLE ALEEGERQGG GSKQKALIDD LPLFAAIPPA
PPPAAKPAPS PALEMLEKIH PDELTPREAL QLLYDLKEKA RQ
//
