ID A0A1M4NBN9_9CLOT Unreviewed; 617 AA.
AC A0A1M4NBN9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=UDP-N-acetyl-alpha-D-glucosamine C6 dehydratase {ECO:0000313|EMBL:SCN23792.1};
DE EC=4.2.1.135 {ECO:0000313|EMBL:SCN23792.1};
GN Name=pglF {ECO:0000313|EMBL:SCN23792.1};
GN ORFNames=N3C_1498 {ECO:0000313|EMBL:SCN23792.1};
OS Clostridium sp. N3C.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1776758 {ECO:0000313|EMBL:SCN23792.1, ECO:0000313|Proteomes:UP000184869};
RN [1] {ECO:0000313|EMBL:SCN23792.1, ECO:0000313|Proteomes:UP000184869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N3C {ECO:0000313|EMBL:SCN23792.1};
RA Seilhamer J.J.;
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; FMJL01000019; SCN23792.1; -; Genomic_DNA.
DR RefSeq; WP_074365418.1; NZ_FMJL01000019.1.
DR AlphaFoldDB; A0A1M4NBN9; -.
DR STRING; 1776758.N3C_1498; -.
DR OrthoDB; 9803111at2; -.
DR Proteomes; UP000184869; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:SCN23792.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184869};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 291..573
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 617 AA; 70278 MW; ED28C1B423D0AA39 CRC64;
MRKINKLIII DIVFVILSLY LAFLLRFDFG MDNAYKEYLN FAMMSIVPFV IITIACNYLF
SLYSRIWRYA SVEELLSIVL SVSLSNVLFI VYSYVINYKV LHTSYFRFPF SMHIIAWIIS
VALLGGVRFI FRIGDAANQF KEGTTGKKKL LIIGAGEAAA MLIREIKNHR ELNYNIIGLI
DDDVSKLGRK IKGVKVLGDR SDIEKVCKEY KVDEIIVAIP SADNKTKREI YNKCKNTKCK
LKTLPGIYEL IDNKKIEISK IRDVNIEDLL GREEVHLNIE GISKYVKDKV VLVTGGGGSI
GSELCRQVAK FDPSKLLVLD IYENGAYDLQ MQLKYDYPDL DLEVVIASIR DYERLKQLFE
QYKPDVVFHA AAHKHVPLME DNPSEAIKNN ILGTYNLLNC ARDYKVKKFV QISTDKAVNP
TNIMGATKRF CEIMVQAFDK VSETEFVAVR FGNVLGSNGS VIPLFKEQIA KGGPVTVTHP
EINRFFMTIP EAAQLVLQAG AMADGGEIFV LDMGKPVKIV DLARDLIRLS GLKPDEDIKI
KYTGLRKGEK LYEELLMSEV ALTSTNHEKI FVEKPMEYDM EFVKQSVEEF QNIIYSDKEE
IFKLIQKKVP TYKRNLN
//
