ID A0A1M4S085_9ACTO Unreviewed; 486 AA.
AC A0A1M4S085;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Sodium:alanine symporter {ECO:0000313|EMBL:SHE25540.1};
GN ORFNames=ACGLYG10_1759 {ECO:0000313|EMBL:SHE25540.1};
OS Actinomyces glycerinitolerans.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1892869 {ECO:0000313|EMBL:SHE25540.1, ECO:0000313|Proteomes:UP000184291};
RN [1] {ECO:0000313|Proteomes:UP000184291}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Strepis N.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC ECO:0000256|RuleBase:RU363064}.
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DR EMBL; FQTT01000011; SHE25540.1; -; Genomic_DNA.
DR RefSeq; WP_073330663.1; NZ_FQTT01000011.1.
DR AlphaFoldDB; A0A1M4S085; -.
DR STRING; 1892869.ACGLYG10_1759; -.
DR OrthoDB; 9806926at2; -.
DR Proteomes; UP000184291; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR001463; Na/Ala_symport.
DR NCBIfam; TIGR00835; agcS; 1.
DR PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR Pfam; PF01235; Na_Ala_symp; 1.
DR PRINTS; PR00175; NAALASMPORT.
DR PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363064};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW Reference proteome {ECO:0000313|Proteomes:UP000184291};
KW Symport {ECO:0000256|RuleBase:RU363064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363064};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363064};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 222..243
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 249..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 359..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363064"
SQ SEQUENCE 486 AA; 50439 MW; 6BE59D322E52D681 CRC64;
MEALADSLLS IADWITAHIT MWVLVGTGLF LTIRTRAVQV RHLPNMFRAV SSSRAGAHGG
ISSFQAFAIS LAARVGVGNI FGVAAALLMG GPGAVFWMWV VALVGMATAF FEATLAQIFK
VRADDGSFRG GPAYYMRSGV GSPALAGVYA VITLVTCGFI ITSVQSNAVA GTLLGAIGDD
GSAIEGFGGF SAAQLVIAAL VFVFTAMVIF GGIRTVARVT EWMAPIMAGI YIVLVFIICL
MHLGRFVEVL GLIISSAFAP QPLVGGLGGG ILAAVVNGTK RGLFSNEAGQ GTAPNAAATA
TVAHPVQQGL IQSLGVFIDT IVVCTATAFV ILIAGPEVWG ANGANPSTLT IMAVSHELGG
WTILPIAVLI FVLAYSSIIA AYVYSDTNMS FLTGGKTWAT WTVRVVSVVS ATAGAVLSLD
VVWNAVDIAM AVMTVTNLVA LILLSKWGVG ALRDWEAQRR AGVEEPVFVG HDNPHLPADV
PGDVWN
//
