ID A0A1M4SQG2_9FIRM Unreviewed; 463 AA.
AC A0A1M4SQG2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=SAMN02745190_00213 {ECO:0000313|EMBL:SHE34415.1};
OS Schwartzia succinivorans DSM 10502.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Schwartzia.
OX NCBI_TaxID=1123243 {ECO:0000313|EMBL:SHE34415.1, ECO:0000313|Proteomes:UP000184404};
RN [1] {ECO:0000313|EMBL:SHE34415.1, ECO:0000313|Proteomes:UP000184404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10502 {ECO:0000313|EMBL:SHE34415.1,
RC ECO:0000313|Proteomes:UP000184404};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
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DR EMBL; FQUG01000002; SHE34415.1; -; Genomic_DNA.
DR RefSeq; WP_072934334.1; NZ_FQUG01000002.1.
DR AlphaFoldDB; A0A1M4SQG2; -.
DR STRING; 1123243.SAMN02745190_00213; -.
DR OrthoDB; 9808591at2; -.
DR Proteomes; UP000184404; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21124; SPASM_CteB-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR024025; SCIFF_rSAM_maturase.
DR InterPro; IPR047602; SPASM_CteB-like.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR NCBIfam; TIGR03974; rSAM_six_Cys; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000184404};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 89..320
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 463 AA; 52762 MW; 89B42E6C1DBC8E7C CRC64;
MKDRIHKFEQ NGTYILLDIN SGAVHVIDKM IYDMMDTFDG TNDNEVLKAL DGKYPKEDLT
EALEELHELM KMQQLFAPDI DIPPTFAQTG IVKSLCLMIA QDCNLRCKYC FGDGGSYGQE
RAVMSPETGK KAVDFLIEKS GPRKHCEMDF FGGEPLMNMK TVKAVTEYVH QREKETGKKI
KLTLTTNGML LNDDNIKWLN ENDFSLVLSL DGRKEVHDAM RPDVGGNGTY DRVVKNFKKC
LDSRKGGNYD YRGVYTFLRG TYTKNSMDFT EDVLSMNDAG FDILSMEPVV LKDSPLGFTE
EDLPRINEEY DRLTEAYMKR HREGKGFFFF HFNMDLSNGP CVAKRLSGCG AGHEYFAVAE
NGDLYPCHQF VGREKYRLGS LDEGVTSKDL PQYFRESHVL NKPKCRDCWA RFYCSGGCHA
NADLFHGDIR QPYEVGCEIQ KKRLECAILV QALLKLEKEN NEG
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