ID A0A1M4STG5_9FLAO Unreviewed; 340 AA.
AC A0A1M4STG5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569, ECO:0000256|RuleBase:RU366046};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN ORFNames=SAMN05444278_101319 {ECO:0000313|EMBL:SHE35481.1};
OS Psychroflexus salarius.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Psychroflexus.
OX NCBI_TaxID=1155689 {ECO:0000313|EMBL:SHE35481.1, ECO:0000313|Proteomes:UP000184462};
RN [1] {ECO:0000313|EMBL:SHE35481.1, ECO:0000313|Proteomes:UP000184462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25661 {ECO:0000313|EMBL:SHE35481.1,
RC ECO:0000313|Proteomes:UP000184462};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC ECO:0000256|RuleBase:RU366046};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU366046};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
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DR EMBL; FQTW01000001; SHE35481.1; -; Genomic_DNA.
DR RefSeq; WP_073191083.1; NZ_FQTW01000001.1.
DR AlphaFoldDB; A0A1M4STG5; -.
DR STRING; 1155689.SAMN05444278_101319; -.
DR OrthoDB; 9801785at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000184462; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR PRINTS; PR01713; NUCEPIMERASE.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW Isomerase {ECO:0000256|RuleBase:RU366046};
KW NAD {ECO:0000256|RuleBase:RU366046};
KW Reference proteome {ECO:0000313|Proteomes:UP000184462}.
FT DOMAIN 4..326
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 340 AA; 37869 MW; 11C4D40505A7DE58 CRC64;
MKILVTGGLG FIGSHTVVEL QQKNYEVVII DNLSNSSIDV LSGIEKITGK TPEFHNFDLC
EREKVNQFFK NHQDLSGIIH FAASKAVGES VENPLLYYEN NINTLVYLLK AQTQFQQANF
IFSSSCTVYG EADKLPITED APVKQAESPY GNTKQIGEEI IRDTAKTYSH FKAIALRYFN
PIGAHESAEI GELPIGTPQN LVPYITQTAA GIRNELSIFG DDYPTVDGTC IRDYIHVVDL
AKAHVVALER QLQDSCKTNF EVFNLGTGKG SSVKEVVQTF ERVTNQELPH KIVSRREGDV
VAAYADTQKA KNELGWATKL TLDDALASAW KWQLKLRQTH
//
