ID A0A1M4TXJ3_9GAMM Unreviewed; 389 AA.
AC A0A1M4TXJ3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=SAM-dependent methyltransferase {ECO:0000313|EMBL:SHE49027.1};
GN ORFNames=SAMN02745204_00538 {ECO:0000313|EMBL:SHE49027.1};
OS Thermomonas hydrothermalis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Thermomonas.
OX NCBI_TaxID=213588 {ECO:0000313|EMBL:SHE49027.1, ECO:0000313|Proteomes:UP000242857};
RN [1] {ECO:0000313|Proteomes:UP000242857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14834 {ECO:0000313|Proteomes:UP000242857};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmI family.
CC {ECO:0000256|ARBA:ARBA00038091}.
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DR EMBL; FQUK01000006; SHE49027.1; -; Genomic_DNA.
DR RefSeq; WP_072755093.1; NZ_JAILZK010000049.1.
DR AlphaFoldDB; A0A1M4TXJ3; -.
DR STRING; 213588.SAMN02745204_00538; -.
DR OrthoDB; 9805492at2; -.
DR Proteomes; UP000242857; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11572; RlmI_M_like; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR Gene3D; 3.30.750.80; RNA methyltransferase domain (HRMD) like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR041532; RlmI-like_PUA.
DR InterPro; IPR019614; SAM-dep_methyl-trfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42873:SF1; METHYLTRANS_SAM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42873; RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE; 1.
DR Pfam; PF10672; Methyltrans_SAM; 1.
DR Pfam; PF17785; PUA_3; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SHE49027.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242857};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SHE49027.1}.
FT DOMAIN 13..67
FT /note="RlmI-like PUA"
FT /evidence="ECO:0000259|Pfam:PF17785"
FT DOMAIN 175..303
FT /note="S-adenosylmethionine-dependent methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF10672"
SQ SEQUENCE 389 AA; 43640 MW; 58AB8941B395236D CRC64;
MADPLPVIRL KNAWNSTHPW IFQRLVEKPA QRPKPGSVVD VVGVDGAFIG RGFYNGHSRI
AVRILERDPE VPVDAGWFVR KIGEAVRLRR EILKLDEITN AWRVVHSEGD GISGLVVDRY
DDLIVVEFFS AGAWRHRSLI FDALRTHFPG CRFHSFADEH VQKQESFDYK ETQGTAPAIV
SEYGVKFRAD PAGAHKTGFF ADQRENRHWV AQQCQGLRVL DLCCNTGGFA VHAAVRGAHE
VVGIDIDPAV IEIAKQNAHL NQVRPRFVQA DIFPWLRDAA ANGERFDVVI LDPAKMTRDR
EQVIPALKKY LDMNKLALGV VKPGGLFATF SCTGLVSEEQ FLDMLRRAAF YAGRTVQVLK
VAGAGPDHPW QVQVPESRYL KAVFCRLLD
//
