ID A0A1M4V8W9_9RHOB Unreviewed; 855 AA.
AC A0A1M4V8W9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:SHE65330.1};
GN ORFNames=SAMN05444339_101991 {ECO:0000313|EMBL:SHE65330.1};
OS Loktanella atrilutea.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Loktanella.
OX NCBI_TaxID=366533 {ECO:0000313|EMBL:SHE65330.1, ECO:0000313|Proteomes:UP000183987};
RN [1] {ECO:0000313|Proteomes:UP000183987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 29326 {ECO:0000313|Proteomes:UP000183987};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; FQUE01000001; SHE65330.1; -; Genomic_DNA.
DR RefSeq; WP_072856016.1; NZ_FQUE01000001.1.
DR AlphaFoldDB; A0A1M4V8W9; -.
DR STRING; 366533.SAMN05444339_101991; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000183987; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR022249; DUF3772.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF12607; DUF3772; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000183987};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..855
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013336276"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 171..224
FT /note="DUF3772"
FT /evidence="ECO:0000259|Pfam:PF12607"
FT DOMAIN 633..700
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 709..790
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 26..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 91039 MW; 97480406ED9E53C0 CRC64;
MIRALPTALA LLLVVAQGTS AQVSLDGLIG APTPTEEPTT EAGDPPSEEA ETASPKEAEA
DTEALTDAQQ ALSQAVPDLD EWKTRVDQAE TLLQAGSGST LALTRTRETL FGWRDRFQSL
GSLNAGRIAT VQSQIEALGP VPEGGEEQPA IAARRAELNR QLDVLRAPAI LAKEAYARAD
GLISEVDSQL RARETTRLTA RGPSPLNPAN WPAALEGGRD ALGGVLSAAM ARVDRNLSSG
TLLRTLPLAV LYMVAALVLL LRSRQWVWLL QDRVERSHAR GRAVWSFLLS LWVIVLPTLG
LSALILALRQ IGVLARSGDT LSQAIFGAGF TIIIARWLNG QLFPVGEHGG PLGYPPDIRA
KIRRNGVALG VGLAAIIVVS ALMHSAGASD AAIGVMVLPL QVLLAVVLFR LGYLLRHAPM
ERDGREISSG RVRTTVGLLC MIVAIVTPIL AAAGYAAASD ALFAPAVMTL AIFGVIIVLQ
RLVYDIYAPT TDSTDTGPLM PVVIGAVLFL LAVPVLALVW GARVTDLLEV WAQFRAGFQI
GETTISPTDF MTFVLIFGGG YLLTQFVKRQ LKTSVLPRTR MDLGGQNAVA AGVAYIGIIV
SALVAITTAG IDLSSLAIVA GALSVGIGFG LQTIVQNFVS GIILLIERPI GEGDMIEVNG
QVGFVRDISV RSTRIETFDR TDVIIPNADL VSGQVTNWTR GNLVGRLIIP VGVAYGSDVE
QVRRILLEVG ESQPMVLADP GPQALFMAFG ASSLDFELRV ILRDVNWKVI VTDEMNRDID
RRFAEAGIEI PFAQQDIWLR NPEALHAPRT SAPAEPSADT AAPDDDRPDT AREASAMMDA
GDLHDGDAAP EAETQ
//
