ID A0A1M4VM00_9ACTN Unreviewed; 370 AA.
AC A0A1M4VM00;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN ORFNames=SAMN02745225_01365 {ECO:0000313|EMBL:SHE69873.1};
OS Ferrithrix thermotolerans DSM 19514.
OC Bacteria; Actinomycetota; Acidimicrobiia; Acidimicrobiales;
OC Acidimicrobiaceae; Ferrithrix.
OX NCBI_TaxID=1121881 {ECO:0000313|EMBL:SHE69873.1, ECO:0000313|Proteomes:UP000184295};
RN [1] {ECO:0000313|Proteomes:UP000184295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19514 {ECO:0000313|Proteomes:UP000184295};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
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DR EMBL; FQUL01000017; SHE69873.1; -; Genomic_DNA.
DR RefSeq; WP_072790347.1; NZ_FQUL01000017.1.
DR AlphaFoldDB; A0A1M4VM00; -.
DR STRING; 1121881.SAMN02745225_01365; -.
DR GeneID; 78386067; -.
DR OrthoDB; 9815130at2; -.
DR Proteomes; UP000184295; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 1.20.120.640; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:SHE69873.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000184295}.
FT DOMAIN 18..310
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
SQ SEQUENCE 370 AA; 40623 MW; 9E3AB0CD71698FB7 CRC64;
MRIFDTKARE KVPLEVGETV RIYTCGITPY DAAHVGHAAV YLTFDILQRR LIDMGVRALC
VRNVTDVDDD ILRKARELDC NYLDLAASEM AKFDANMAAL GVLACYSEPR ATSAIPEILS
LISDLFEKGH AYEVGGWVYF DVTTFADFGG LSHYHYEEMI TLSAERGADP DDPRKRNPLD
FVLWQPSAPG EPSWESRYGA GRPGWHIECS ALAMRELGET IDIHGGGSDL IFPHHECEIA
QSESATGKTF SRYWMHVGMV NLDGIKMSKS LGNLVFVGDL LKRHSPGAVR LAIASNHYKS
SWDFSEGLVE IEEERLARWK RAGAGSGALD EVRAHLDDDL DVKGAVSAID EAVSKGQGVS
TSAALLGVTL
//
