ID A0A1M4VVM6_9BACT Unreviewed; 1438 AA.
AC A0A1M4VVM6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SHE73019.1};
GN ORFNames=SAMN05444362_10254 {ECO:0000313|EMBL:SHE73019.1};
OS Dysgonomonas macrotermitis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Dysgonomonas.
OX NCBI_TaxID=1346286 {ECO:0000313|EMBL:SHE73019.1, ECO:0000313|Proteomes:UP000184480};
RN [1] {ECO:0000313|Proteomes:UP000184480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27370 {ECO:0000313|Proteomes:UP000184480};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; FQUC01000002; SHE73019.1; -; Genomic_DNA.
DR RefSeq; WP_062176827.1; NZ_FQUC01000002.1.
DR STRING; 1346286.SAMN05444362_10254; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000184480; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184480};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 870..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1006..1031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1043..1061
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1438 AA; 160447 MW; 7098B2A90ADE24C9 CRC64;
MFKSIVRFSI RKKLFVALTT FFLLLGGIYA MLTLPVDAVP DITNNQVQIV TVSPTLAPQE
VEQLITFPIE IAMSNIMNVK EIRSVSRFGL SLVTVVFEED VPTLAARQLI NEQIQTVIDE
IPSELGTPEL MPITTGLGEI YQYVLNVAPG YEDKYDAMEL RTIQDWIVKR HLSGIPGIVE
INSFGGYMKQ YEVAVDPDAL YAMDITIGDV YTALQSNNQN TGGSYIEKVN RAYYIRSEGM
IEDISDIEQI VVANRGGIPI HIDAIGSVRF GSPKRFGAMT KDGKGECVGG IAMMLKGANA
SAVTKELESR VEKVQKLLPE GVTIEPYLNR SELVTRNIST VIFNLIEGAL IVFLVLIIFL
GNVRAGLIVA SVIPLSMLFG FILMRLFGVS ANLMSLGAID FGIVVDGSIV IVEGILAYIY
SSRLAGRTLT PQQMDAEVEA GAGEVVRSAT FAVLIILIVF FPILTLTGIE GKYFTPMAKT
LVFCIIGALI LSLTYVPMMA SLFLKRTINN KLTFADRFFN KLNSIYKRVL NKSIRFAGLT
VIIAFTALGA SLLLFNRLGA EFIPTLDEGD FAMQMTLPAG SSLSRSIEIA DQAEKILLKN
FPEIKHVVSK IGTAEVPTDP MAVEDADIMI IMKPFKEWTT ADSRAEMVEK MKESLDIIPD
VEFNFSQPIQ LRFNELMSGT KADIAIKLYG EDTEELYKKA KEAARFVEQV PGAADVLVEQ
TMGLPQLIVK YDRAKIARYG MNIEELNTII RTAYAGEAAG VVFENERRFD LVVRLNNDKV
PELNLDKLYV RAAEGSLIPV TEVADVEYRS GPLQINRDAT KRRIVIGVNV RDGDIQNVVE
QIQTTLDENM KLKPGYYFEY GGQFENLQNA ISTLTVVIPV ALMLILLLLF FAFRSIVYTL
VIFTTVPLSL IGGILALWLR DLPFSISAGV GFIALFGVAV LNGILMINHF NALRMKNRYA
LSTHKIIEKG CPHLLRPVFL TGLVASLGFV PMAIATSAGA EVQRPLATVV IGGLIISTLL
TLIIIPVLYR TVNSTVVWKR KGWYKKIFAG LILLILPYLG INAQVKVTLD QAVSMALENH
PRLTSANASI ERTKAMRGEA WEIPATSFSY SWGQLNGTDK NDNEFQINQS FGSLLTPYYK
NALVSKQVTT GENYKEIVKK EIIAEVKRAW VNYLYVTHQL SLYEEQNEWI QRLRKATQLR
YEQGDITLLD RNSATALSAD MSTRLLQTQE ELRIATRRLA WVCYSETDLI PADTAFVEVP
LDMFPIKSLS LSHINYLESL SAEKAAQISI EKSRFFPEIS LGYSRQKIAP LTGLDSWTVG
ISIPLFFNQQ KSRIKQAKID YYISTIENEY QKKEFSNKID ELLARAKQQK ESVDYYRKGA
LPEADALMQS ASLQFYESDT DIMQFIQSFN TVRDIKLGYL EALYNYNVSL LELELYTK
//
