ID A0A1M4VYP5_9BACT Unreviewed; 306 AA.
AC A0A1M4VYP5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:SHE74069.1};
GN ORFNames=SAMN05444362_10275 {ECO:0000313|EMBL:SHE74069.1};
OS Dysgonomonas macrotermitis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Dysgonomonas.
OX NCBI_TaxID=1346286 {ECO:0000313|EMBL:SHE74069.1, ECO:0000313|Proteomes:UP000184480};
RN [1] {ECO:0000313|Proteomes:UP000184480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27370 {ECO:0000313|Proteomes:UP000184480};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; FQUC01000002; SHE74069.1; -; Genomic_DNA.
DR RefSeq; WP_062176775.1; NZ_FQUC01000002.1.
DR AlphaFoldDB; A0A1M4VYP5; -.
DR STRING; 1346286.SAMN05444362_10275; -.
DR OrthoDB; 9778880at2; -.
DR Proteomes; UP000184480; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR PANTHER; PTHR42849; N-ACETYLNEURAMINATE LYASE; 1.
DR PANTHER; PTHR42849:SF1; N-ACETYLNEURAMINATE LYASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00666; DHDPS_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000184480};
KW Schiff base {ECO:0000256|ARBA:ARBA00023270}.
FT ACT_SITE 139
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 167
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 51
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
FT BINDING 211
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 306 AA; 33386 MW; CE75BC003E729121 CRC64;
MNTPKKTLRG IVPPMITPLI DTDTLDTKGV ENLVEHLIKG GVSGIFILGT TGEAQHLSVK
IKTELIKKTC VCVNGRVPVL VGITDTSVYE SIKLAEVAAE YKAEAVVAAP PYYFALGQPE
LIEYYTLLAD KCSLPLYLYN MPSHTKTMIE PGTVMALSKH KNVIGLKDSS ANGVYFCKLL
SMFKDQPEFE LFVGPEEMMA SVVLMGASGG VSGGANVYPE IFVDVYNAAA NKNVDKTIEL
QNKMMLVSQE LYGIGRFGSS YIKGIKTALS LKGICSDFLA QPFNLFKDPE KEKVKIAVEK
LDKLLK
//
