ID A0A1M4W7H4_9FLAO Unreviewed; 1118 AA.
AC A0A1M4W7H4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN05444377_101199 {ECO:0000313|EMBL:SHE77100.1};
OS Flavobacterium fontis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1124188 {ECO:0000313|EMBL:SHE77100.1, ECO:0000313|Proteomes:UP000184147};
RN [1] {ECO:0000313|EMBL:SHE77100.1, ECO:0000313|Proteomes:UP000184147}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25660 {ECO:0000313|EMBL:SHE77100.1,
RC ECO:0000313|Proteomes:UP000184147};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQVQ01000001; SHE77100.1; -; Genomic_DNA.
DR RefSeq; WP_073360521.1; NZ_FQVQ01000001.1.
DR AlphaFoldDB; A0A1M4W7H4; -.
DR STRING; 1124188.SAMN05444377_101199; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000184147; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000184147}.
FT DOMAIN 575..736
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 745..911
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1118 AA; 128857 MW; 4ABA4ED29B93B4A3 CRC64;
MSKSTLLSVY QASPKVEQLA VALRQPEAKI NVRGLLGSGL SFALAALFEK MDRPFLVVFN
DKEEAAYYLN DWEQLLNEQD VLFYPGSYRR PYQLEETDNA NILLRAEVLN RLNSRKKPPF
LVTYAEALFE KVVTKKELEK NTLKIAVNDQ TSIDFINEVL FEYHFKRVDF VTEPGEFSVR
GGIVDVFSFS NDHPYRIEFF GNEVDSIRSF DVETQLSIEK LKKIAIIPNV EHKFFEENRE
RFLDYIDPST VLFFQHSEIL GQQLDKLFAK ATEAFQTLDN GIRHVSPEEL FVHGTDLLQR
AERFTVVELG NQVHYPCTMT LPFLMQPQPS FNKQFDLLLQ NLGENHFHGY KNYLFCGNAN
QAQRFHDIFE DIDEQNHESI RKQYHTVVMP LYQGFIDEEN QLVCYTDHQI FERYHRFNLK
NGYSKKQTLT LKELTSLTVG DYVTHIDHGI GKFGGLQKIQ VEGKTQEAIK LVYADNDIVY
VSIHSLHKIS KYNGKDGTPP KIYKLGSNAW KALKQKTKAR VKHIAFNLIQ LYAKRRTERG
FACAPDSYLQ KELESSFIYE DTPDQYKATQ DVKTDMESER PMDRLVCGDV GFGKTEVAIR
AAFKAVDNGK QVAVLVPTTI LAYQHYRTFS ERLKDLPVTI HYLNRFRTAK QKNETLKLLE
EGKVDIIIGT HQLVSKDVKF KDLGLLIIDE EQKFGVNVKD KLKTISHTVD TLTLTATPIP
RTLQFSLMAA RDLSVITTPP PNRYPIETQV VRFHEELIRD AVSYEIQRNG QVFFIHNRIE
NIKEVAGMIQ RLVPDARIGI GHGQMDGKKL EELMLAFMNG EFDVLVSTSI IESGLDVPNA
NTIFINNANN FGLSDLHQMR GRVGRSNKKA FCYFITPPYS AMTDDARKRI HALEQFSELG
SGFNIAMKDL EIRGAGDLLG GEQSGFINEI GFETYQKIMN EAIEELKENE FKELYPQDND
PETKEYVKDL QIDTDFELLF PDDYINNITE RLNLYNELSA IKDEKSLAEY EQRVVDRFGP
LPKPAKALIN SIRIKWKATQ LGIEKLLLKQ DKMVGYFIGD QQSDFYQTQR FMQILEFVQR
HGNLCKIKEK QTKNGLRLLI TFEHVKSIHK ALELIEQL
//
