ID   A0A1M4W7J5_9GAMM        Unreviewed;       660 AA.
AC   A0A1M4W7J5;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SHE76942.1};
GN   ORFNames=SAMN04487965_0617 {ECO:0000313|EMBL:SHE76942.1};
OS   Microbulbifer donghaiensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Microbulbiferaceae; Microbulbifer.
OX   NCBI_TaxID=494016 {ECO:0000313|EMBL:SHE76942.1, ECO:0000313|Proteomes:UP000184170};
RN   [1] {ECO:0000313|EMBL:SHE76942.1, ECO:0000313|Proteomes:UP000184170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.7063 {ECO:0000313|EMBL:SHE76942.1,
RC   ECO:0000313|Proteomes:UP000184170};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
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DR   EMBL; FQVA01000001; SHE76942.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M4W7J5; -.
DR   STRING; 494016.SAMN04487965_0617; -.
DR   Proteomes; UP000184170; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          290..583
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
FT   REGION          638..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  72958 MW;  28AF00E3D08DC4E4 CRC64;
     MGKWGKSGGY VTRIWRTVHK HHKPVLMLLF DLLMLSFAFV MAMAIRVNGL SPALEVEMLI
     CLALTLASSS FIFLRLGLYR TVIRYMGQQA IVAVLQGVTA SAVVLAVASY LTFAGVPRSV
     PVIYWCFALI AVGGSRWLVR IYYQMALEIH KTRVAIYGAG TAGLQLYKAL VHGEIYKPVA
     FFDDNASKQK TLIDGVLVYN PSNILDVVVE RDISEVLLAM PGVPKRRRRE ITRGLRERGL
     VVKVIPGLEE LVDGAGRTAD VSQIYENILG RAPVEPEKAL IAGSISGKVV LVTGAGGSIG
     SELCRQIALW RPAHLVLVES SEYALYQIER ELYQQQQDEG HQLKVTALLG DVRDRVRMAE
     IIESFSIHTI YHAAAYKHVP LVEQNVVLGA DNNVLGTLSV LEAAEAFGVE QFVLISTDKA
     VRPTNVMGAT KRFAELVCQD FGRRFAKTRV CMVRFGNVLG SSGSVIPLFT DQINAGGPVT
     VTHPKVTRYF MTIPEAAQLV LQAGSMGRNG DVFVLDMGEP VRIYDLAKRL IQIMGHTVRD
     EENPDGDIEI QITGLRPGEK LYEELLLGDN VSGTDHPMIM RAEEERLASE RLQTLIGGLR
     QACTRHDCEE VHRILMEAVK DYAPKQSLVD VVWTQRRESK PAPQVGQVER LPLPVDAGRR
//