ID A0A1M4W9T1_STRHI Unreviewed; 625 AA.
AC A0A1M4W9T1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Zn-dependent protease with chaperone function {ECO:0000313|EMBL:SHE77969.1};
GN ORFNames=SAMN05444320_1011062 {ECO:0000313|EMBL:SHE77969.1};
OS Streptoalloteichus hindustanus.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Streptoalloteichus.
OX NCBI_TaxID=2017 {ECO:0000313|EMBL:SHE77969.1, ECO:0000313|Proteomes:UP000184501};
RN [1] {ECO:0000313|EMBL:SHE77969.1, ECO:0000313|Proteomes:UP000184501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44523 {ECO:0000313|EMBL:SHE77969.1,
RC ECO:0000313|Proteomes:UP000184501};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FQVN01000001; SHE77969.1; -; Genomic_DNA.
DR RefSeq; WP_073480080.1; NZ_FQVN01000001.1.
DR AlphaFoldDB; A0A1M4W9T1; -.
DR STRING; 2017.SAMN05444320_1011062; -.
DR OrthoDB; 155290at2; -.
DR Proteomes; UP000184501; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07328; M48_Ste24p_like; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR001915; Peptidase_M48.
DR PANTHER; PTHR43221; PROTEASE HTPX; 1.
DR PANTHER; PTHR43221:SF1; PROTEASE HTPX; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SHE77969.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000184501};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 41..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 136..306
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
FT REGION 588..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 67357 MW; 3251A50A504A145F CRC64;
MRSPWRAVLA LTVLVGFFAC AAVLAAGLAG AALYAMADGD IGMTAIELLL CSALLGTAVG
LFLPPVLRVR HRARGHVVDR AAQPELWEVI DELAGIARSR PPDELRVVPG VRIAFWEDAP
VLGLVPGHRC LEVGLPLLGG LTVAELRAVL AHELAHLGDR EGRPHAVAYR ATALVEQVVA
DSEGDWRRPV LRAWGNLVLS VAAPVNQRQE QVADEAAVAA AGVEAACAAF RRMAALERAW
SDYGQQYLAM APIARRTPDV LLGFRSYLSA PRRQREWAEL EDEALDAGPS GPHDRHAPLR
ERIEAMRAAG GEEPEADDRP AWSLLTSPGR SVPELEDALL VDLGPRAPWP ELVRAAVVRK
AEDAARRLSR AVLDSGVRVD GRAAQTTVAG VLLAVHRGLG CELVKPALDP GLAPGEVSAA
SDALLVELLG GAVTAALCRT GRARPELNWD GPCWLRLASG QVVDVERLVG PAVRTPGLVP
QLHRHLVRIG VPLDFAARPA EPPEPELVAS ANGVRCDGDP HDVRVYDSGL LVLPAGSPAR
KPLPELRRRP GARWVCGHDV EWARLVHRQS GWDVWLQLRG GDELELTSAS DTAHDGDPQE
GMARLLGDRL EVEDVRQRRR EPVHR
//
