ID A0A1M4XQK3_9CLOT Unreviewed; 747 AA.
AC A0A1M4XQK3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=EAL domain, c-di-GMP-specific phosphodiesterase class I (Or its enzymatically inactive variant) {ECO:0000313|EMBL:SHE95735.1};
GN ORFNames=SAMN02745158_02078 {ECO:0000313|EMBL:SHE95735.1};
OS Lactonifactor longoviformis DSM 17459.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Lactonifactor.
OX NCBI_TaxID=1122155 {ECO:0000313|EMBL:SHE95735.1, ECO:0000313|Proteomes:UP000184245};
RN [1] {ECO:0000313|EMBL:SHE95735.1, ECO:0000313|Proteomes:UP000184245}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17459 {ECO:0000313|EMBL:SHE95735.1,
RC ECO:0000313|Proteomes:UP000184245};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FQVI01000009; SHE95735.1; -; Genomic_DNA.
DR RefSeq; WP_072851370.1; NZ_FQVI01000009.1.
DR AlphaFoldDB; A0A1M4XQK3; -.
DR STRING; 1122155.SAMN02745158_02078; -.
DR OrthoDB; 9762141at2; -.
DR Proteomes; UP000184245; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184245};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..484
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 494..747
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 747 AA; 85062 MW; B8F968388D99D57F CRC64;
MHKTQMSLSH RRRPVITTGL QLSILSVILI IIIVLTLWNT SNLRSVINYS TENYAEDVTC
QLADDIAARL ESNQQYMILL ADSISKIDYR TDTAALKEFL NRKAEILDFD TIIFLDAQGN
AIPSVSDARD LWNLPSVQGS LQGNSEVTYI EGQSLLYSTP VYSGSEITGV LTGIRKKESI
QSLIQPKAFS GESLTCIVDN SGEVVVSPTE LKPFLQLNDI FKSGKDRNTE NEILKMMDDM
KANRGGVFPF TAVNGDELIM SYHPLNVNQW VLLTLIPADL ISHGADVYTV KTFLIIGGIA
AVFILFLVSI LRFYSYHRRY LEQLAFSDPV TGGMNYSAFQ LQYEELVKAA PPLTYTVIML
NVKGFKLINE NYGTSAGNDT LRYIYRILLR HMESGEFAAR NEADNFFLCI KEMEKQTIQF
RLDAIIHDIN SFNETRETPY YLMILQGAYL VDDPTLELTI IQDRTRTAYQ NQDSGTHPAC
AFYDADFTKQ LQTEQELNDL FEHSLKNHDF KVYLQPKVRL LDGGIAGAEA LVRWIHPQKG
IIFPSDFIPI FEHNGKICHL DLYMFEEVCR LLEQWNQKGQ PWIPISVNLS RQHFKNPEFL
KAFSEIAERY HIPPNTIEFE LTESILFDPQ QIEVVKISIQ KMHALGFLCS LDDFGSGFSS
LGLLKEFDVD TIKLDRQFFL DISKEKSRDV IACLIELAKK LNVRTVAEGI EEQEQLDYLR
EIGCDLVQGY IFSKPLPPKE FEAFCAR
//
