ID A0A1M4YF79_9BACT Unreviewed; 1136 AA.
AC A0A1M4YF79;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=SAMN05444362_103152 {ECO:0000313|EMBL:SHF04308.1};
OS Dysgonomonas macrotermitis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Dysgonomonas.
OX NCBI_TaxID=1346286 {ECO:0000313|EMBL:SHF04308.1, ECO:0000313|Proteomes:UP000184480};
RN [1] {ECO:0000313|Proteomes:UP000184480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27370 {ECO:0000313|Proteomes:UP000184480};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; FQUC01000003; SHF04308.1; -; Genomic_DNA.
DR RefSeq; WP_062177474.1; NZ_FQUC01000003.1.
DR AlphaFoldDB; A0A1M4YF79; -.
DR STRING; 1346286.SAMN05444362_103152; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000184480; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000184480};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1136
FT /note="beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009908437"
FT DOMAIN 787..1120
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1136 AA; 130232 MW; 8F4B6EF0E714FBFE CRC64;
MKKLLIGCLL YLISVNLPAQ DKLPYWKDIN VFSVNKEDAR SAFVSYSNKS EALTGIYENS
KYYQLLNGTW KFYFVDSYKQ LPDNITDPNA STDSWHDIKV PGNWEIQGFG TPIYTNHGYE
FKPRNPTPPL LPEDIPAGIY RRDIEIPADW LGRDIYLHIG GAKSGVYVYI NGQEVGYSED
SKNPAEFNIN KYVKAGKNVL TLKIFRWTTG SYLECQDFLR ISGIERDVYL WSQPKVALKD
FWVVSTLDDS YKNGIFKLAL DIENHEKTTQ KTSVSYELLD AKQRSVAAGS SNIEIKANGK
QAVKFDAILD NVATWTSEKT NLFKLVMTIT SDNGQEVIPF NVGFRRIEIK ESEFEKNGEK
LRLFYINGQP VKLKGVNIHE VSQIGGHYVT PEEMRRDFEL MKLNNINSVR LAHYPQDRKF
YEMCDEFGFY VYDEANIESH GMYYTRYLDD VRKGSYGHKD GTKLGTLGHN PDWLNNHLYR
INNMFQRNKN FPSLTIWSLG NEAGNGYNFY VSYMTLKDLD KDLMNRPVNY ERALWEWNTD
MFVPQYPSAA WLEEIGSKGA DRPIVLSEYA HAMGNSTGDL YGQWEAIYKY PQLQGGYIWE
WKDHGVLMKD EETGRPYWGY GGDWGVDQPS DGNFMCDGLL RSDQTPQPGL TEVKYNYQDI
GFEAIDLEQG VFKIINRFYF TNLSDYLIKY KIYNNGKLLN ETVLDLNTAP QTSAEIKIPY
SSFKHTASGE YFVNFEVFTK QPTQLVPAGH MVAHDQFQLP LAQEEKTYNR DLNNPSLEYA
EEGDNVRIHS SKVDFVFNKK QGIVTSYKVD GTEYFHDGFG IQPNFWRGPN DNDYGNGAPL
RLQTWKQASK NFNVVNVEQM MTTGYTVTMQ VDYLLPAGNY YIMQYSLDRS GVLHISAKFT
ALAKDADDVK KTQEAETATH SPQAASDFEE KAKQKILEVP RIGVRFRLPL EMDNIKYFGR
GPQENYIDRN KGTLVGIYTA KAEDLYFGYA RPQENGHHTD SRWFTATMNN GKGLLVKATE
TIGFNALRNT VEDFDAQEAD APYQWYNFTP EEIANRNEAE AANRRPKQTH ISDITPRNFV
EICVDMKQQG VGGYDSWGSR PISAATIYSN TDYVWSFTIV PVNNNKDAES KASLKY
//
