ID A0A1M4Z591_9FIRM Unreviewed; 863 AA.
AC A0A1M4Z591;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN02745190_01919 {ECO:0000313|EMBL:SHF12967.1};
OS Schwartzia succinivorans DSM 10502.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Schwartzia.
OX NCBI_TaxID=1123243 {ECO:0000313|EMBL:SHF12967.1, ECO:0000313|Proteomes:UP000184404};
RN [1] {ECO:0000313|EMBL:SHF12967.1, ECO:0000313|Proteomes:UP000184404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10502 {ECO:0000313|EMBL:SHF12967.1,
RC ECO:0000313|Proteomes:UP000184404};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FQUG01000007; SHF12967.1; -; Genomic_DNA.
DR RefSeq; WP_072935999.1; NZ_FQUG01000007.1.
DR AlphaFoldDB; A0A1M4Z591; -.
DR STRING; 1123243.SAMN02745190_01919; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000184404; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000184404}.
FT DOMAIN 8..315
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 320..786
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 863 AA; 100276 MW; 7FBC7DFEEA0335AE CRC64;
MENKDVFEQV NEKQRQVIDT LDRNVLLLAS AGTGKTGTLA RRIAKILDKK LAEPEEILCL
TFTNKACQEM KERIVKYVGS PGHKVVVRTI HSFCFDVIRQ EAKRKTDFFT DFMIFDEEDC
AELIAQINPN RLPVGTLQNF INTVKVKRTE YGIFSGDARD DYRDTVRRLF DELGDEGVYN
FFMDSKFEFR AEMASEMAAR GEEYVLLYNR LMHDEHGLDF NDLILGTYDL FRQEEVCMRW
REKFRFINID EVQDTNELEY DILSKLFGDN HILLSGDYYQ TIYEWRGSRP SRIFERFERE
CSPVRIILEE NYRATRTLVQ ASYACLDSFF GGRAAEWEGK IRAASPEKGK PIMLKACMSM
NEEAEWIYHC IENLPCDDPS KVCILTRSNA YNKQLCQYLQ RVTPVERRVD FFLADEMKLF
RRQEVKDALA FVKLTLNKYD AASMKRILKR FVTGIGQKTI DKIESEKMRE SGLRLTDFLD
ESILQDGDSY ARLIREYDAG NVVVFDVEST GVDTTEDEII QIAGVRLGAD GGITGKFNRL
LRNTKPVGMS ETVHHISDEK LAKEGGDPRE VITEFLEFIR GSLIVGHNVS FDLSILLSET
ERLGLSRPDF AGWYDTLDIY RRFYPRLTNH KLESLGAYIK VSHPSTHDAF DDICATAELL
SYAVRENIRP TQDIRRQCIA KYGHFFEQIA GSIAELHREI MRKRPIEFLE CIIKNHLLAY
YRKEERRMEH LRELYRAMRK YDTGEQSTHD TLIRFIRTAA LSTNPLDAGT QRQEKVPIIT
VHQAKGMEFD YVFIAGLHEN GFPSYRAVKD GNRAEEQRLF YTAVTRARKQ LFLSWCQYVK
NHKEQMESTF IASIPKNCIV YCL
//
