ID   A0A1M5AXV0_9FIRM        Unreviewed;      1203 AA.
AC   A0A1M5AXV0;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN02745218_02032 {ECO:0000313|EMBL:SHF35033.1};
OS   Desulfofundulus australicus DSM 11792.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC   Desulfofundulus.
OX   NCBI_TaxID=1121425 {ECO:0000313|EMBL:SHF35033.1, ECO:0000313|Proteomes:UP000184196};
RN   [1] {ECO:0000313|EMBL:SHF35033.1, ECO:0000313|Proteomes:UP000184196}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11792 {ECO:0000313|EMBL:SHF35033.1,
RC   ECO:0000313|Proteomes:UP000184196};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FQUW01000024; SHF35033.1; -; Genomic_DNA.
DR   RefSeq; WP_073165814.1; NZ_FQUW01000024.1.
DR   AlphaFoldDB; A0A1M5AXV0; -.
DR   OrthoDB; 9758506at2; -.
DR   Proteomes; UP000184196; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 6.10.140.1030; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR049035; ADDB_N.
DR   InterPro; IPR014140; DNA_helicase_suAddB.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   NCBIfam; TIGR02773; addB_Gpos; 1.
DR   PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR   PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR   Pfam; PF21445; ADDB_N; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000313|EMBL:SHF35033.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          272..577
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
SQ   SEQUENCE   1203 AA;  134948 MW;  176039A26FF0B00A CRC64;
     MHLRLLIGRA GTGKTRRCLQ EIRAELARNP LGPPLLLIVP DQATFTMERE LAGQGGSLRA
     HVYSFRRLAY RVLREAGGAA RLPVSELGRR MLLKKILLEE RENLKLMGSL AGRPGFLASL
     SELVGELKMH RVAPDDLEGL VPGSGGQLEQ KLEDLCLVYR RLEGELAGIF TDPDDYLDLL
     ARRLPEAGFL KDCRVWVDGF ASFTPQEYAV LQGLSGRARE ITVTLCLDPA AAGCPPEHDP
     FVRPWQVRER LRRLAEEAGL AVREEHLEPG DSWRLAGAPE LAHLERYFFH HPAVPYRGSL
     QNISLMAGVN PRAEVEGIAR AIRRLLREEG LRPREIMVAV RDVDVYFPLF RRMLADYEIP
     FFIDHQQPVM HHPLVELLRS ALEVWQKKWA YEPVFRFLKT GLARLSAGEV DRLENYVLAA
     GIRGSRWYSP DPWNYRPGRT WTGDEEHGEV PPPELEEIDG LRRRAIQELR AAQLKIREEA
     GGRGARLPGR QWARILLELC LELEVPWKLD EWSRAAREAG SPDLAREHRQ VWRLVSGLLG
     ELVEVLGDVE LDLAELSGVL DAGLEALRLA LIPPALDAVT VGSLDRSRPP GEVRALFLAG
     LTEGSLPARL RTTGVFTERE REQLSTLLRE RGRELPAATV DRLHQEQFLI YRVLTRTGGR
     LYLSYPLGDG EGRAVTPSPV IGRVRELLPG LEPRLLAVEP PGGAEDLEYV EHPAGLLSRL
     ALRWREASWG LPVHPLWWWT YNLLVAREEW REKMAVIAAG LAGRNVEPPL GAELGRKLWG
     RREGRKYRLS SSVSRLERFV QCPFAHFLDY GLGLKERAVY RLEPPDTGQL YHEALRLFVE
     RVQGEGPSWE ELGDDKVYGI CAEIVEELAC RLQNRILLSS ARLRQQKARL LERVSDSARA
     LARQMRGSGF RPAALEVYFG LRGTEVPPPA GADAGSLPFW PRLVLPPLEL ELGGEVVLTL
     GGRIDRVDLG RGAEALYLRV IDYKSGSSRL SLPGVLAGVQ LQLLVYLWVA LEHFQLLCRR
     YGRELLPAGA FYFQVQRPIL NLSRPGLSAE ELEREWLKAF RLSGWLVDQG RELYPLLDHA
     LTPGTTSLLV PAGLGSGGSI TRRHEASVFT PGEFRLLLDV LRGLLGKIAG GILQGRVDIA
     PLKAGGSSAC GTCSYRPVCR FDLWLPENRY RNLAVEGGEL RERLRKMAAE EEVGDLDLYS
     LDR
//