ID   A0A1M5BZ25_9GAMM        Unreviewed;       675 AA.
AC   A0A1M5BZ25;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC {ECO:0000313|EMBL:SHF47660.1};
GN   ORFNames=SAMN02745148_02746 {ECO:0000313|EMBL:SHF47660.1};
OS   Halomonas ilicicola DSM 19980.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1121942 {ECO:0000313|EMBL:SHF47660.1, ECO:0000313|Proteomes:UP000184346};
RN   [1] {ECO:0000313|EMBL:SHF47660.1, ECO:0000313|Proteomes:UP000184346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19980 {ECO:0000313|EMBL:SHF47660.1,
RC   ECO:0000313|Proteomes:UP000184346};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000256|ARBA:ARBA00007430}.
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DR   EMBL; FQUJ01000012; SHF47660.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M5BZ25; -.
DR   STRING; 1121942.SAMN02745148_02746; -.
DR   OrthoDB; 9803111at2; -.
DR   Proteomes; UP000184346; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR   PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF13727; CoA_binding_3; 1.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184346};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          284..577
FT                   /note="Polysaccharide biosynthesis protein CapD-like"
FT                   /evidence="ECO:0000259|Pfam:PF02719"
SQ   SEQUENCE   675 AA;  75316 MW;  75D631426CBC4359 CRC64;
     MLSLFRRMFR LPRTYKRIIQ VLVDTLLLTT SFILAMLLRL DSWTPLYEER TWLMVAVLIP
     LSLLIFVHLG FYRAVVRYMS QKALHAILLG VLGSAAAMAI ISYWLDLPIP RSVPIIYAML
     ALLTIGGVRA ILRGLYQRSL MRHKTCVAIY GAGAAGSQLV ASLRHGQEYV PVCFIDDWRG
     MRGTLVEGLK VYAPSELPRL IKEYGVKRVL LAMPSASLGR RREILKMLEP LAVPVQTVPG
     MADVIAGRAR INEIRDVTVE DLLGRDPVPP NQALLDANIR DKVVLVTGAG GSIGSELCRQ
     VLQQRPRRLI LFEVCEYSLY QIEKELLQFS KAAGLAIPIK ALLGSVQQRQ RLEGVMRAFR
     VQTIYHAAAY KHVPLVEHNA IEGIRNNVFG TLETAKAAMA CQVETFVLVS TDKAVRPTNV
     MGTTKRLAEL ICQAFAREQH TTRFCMVRFG NVLGSSGSVV PLFRKQIREG GPITVTHPDI
     TRYFMTIPEA AQLVIQAGAM GNGGDVFVLN MGEPVRISDL AKHMVRLSGL EVLSADSPEG
     DIEIVYTGLR PGEKLFEELL IGDDVTDTAH PRIMAAHESH WEWSKLEGFL QQLQDALIQV
     RHDRIRELLL EAPAAYHPQE QIADLVWIEE KALPAYESEV DGVEVRQAPE TKTATFDLEE
     PIPSSTDWTV SARQR
//