ID A0A1M5DM66_STRHI Unreviewed; 1080 AA.
AC A0A1M5DM66;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05444320_104516 {ECO:0000313|EMBL:SHF67974.1};
OS Streptoalloteichus hindustanus.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Streptoalloteichus.
OX NCBI_TaxID=2017 {ECO:0000313|EMBL:SHF67974.1, ECO:0000313|Proteomes:UP000184501};
RN [1] {ECO:0000313|EMBL:SHF67974.1, ECO:0000313|Proteomes:UP000184501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44523 {ECO:0000313|EMBL:SHF67974.1,
RC ECO:0000313|Proteomes:UP000184501};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FQVN01000004; SHF67974.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1M5DM66; -.
DR STRING; 2017.SAMN05444320_104516; -.
DR Proteomes; UP000184501; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd19067; PfuEndoQ-like; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000184501}.
FT DOMAIN 499..757
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 758..1080
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 435..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..578
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 443..460
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 520..527
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1080 AA; 117659 MW; 77C4F2B1A7160379 CRC64;
MSRSRGKISR VRFHADLHIH SKYSRACSRD CDLEHLTWWA RRKGITLVGT GDFTHPAWFD
HLRENLVPAE PGLFRLRPEL DAAIGRTLPA SCAGEVRFLL SVEISTIYKR DDRTRKVHHL
LYAPDLQVAA AINARLARIG NLGADGRPIL GLDSRHLLEI TLEAGGYLVP AHVWTPWFAV
LGSKSGFDAV EDCYADLAEH VFAVETGLSS DPAMNWRVSG LDRYRLVSNS DAHSPPMLGR
ETTVFDTDLD YFAVRRALET GQGFAGTVEF FPEEGKYHLD GHRKCDVRLE PADTRAREGR
CPECGKPLTV GVLHRVEELA DRPEGARPAG AGEFRSLVPL PEIMSEILGV GPRSKTVLGE
IATLTAALGP ELAILDQVPV ADIAPHSAPL AEAVARLRRG QVIRDAGYDG EYGTIRLFEP
GELRRATLHA VPSLFDDEAF PDPTPTPAAP QAPTPAATAS PAPAGPEAST GEQGMPEASP
DPTGGVAGDD EVPRASLLDG LDPDQRAAAA TTTGPLLIIA GPGTGKTRTL THRLAHLVAT
GQAAPEHCLA ITFTRRAAEE MSERLAALTD RARHLTVATF HSLGLRILRE QHARAGLSAD
FGVADEARRL ALLTELTGDE RQARRAAAAL SRPGDEADPE LAELRQRHTK ALRERDLVDL
DDLVRLPVEI LTADPGLTAA YRDRYRWICV DEYQDVDDTQ YQLLRLLAPP DGNITAIGDP
DQAIYRFRGA DVGFFLRFTT DFPGARTVQL TRNYRSTPPI LSGALQAIAP TSLVPDRVLT
PAVEHPDSPP LGLHQAADEQ AEAAFVARTI DQLLGGSSFH SLDSGRAEGH DGHELSFADI
AVLYRTDSQA RALLDALTRA GVPVQKRSHD RLADRPGVRD ILRELTFRPD TSGGEPVGER
VVDRVRLAAR AALALAPERD REAHAAEVHS ALDLLGPLAT RCGHDLDRFH TELVTGAEVD
TWDPHADLVS LLTLHAAKGL EFPVVFLVGC EDGLLPLRWP GAEDTEAAEA VREERRLFFV
GMTRARRHLY LSHAARRARH GSARPAAPSP FLADIDPALC QRVGDPAPRR RPRSQQLRLL
//