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Database: UniProt
Entry: A0A1M5DM66_STRHI
LinkDB: A0A1M5DM66_STRHI
Original site: A0A1M5DM66_STRHI 
ID   A0A1M5DM66_STRHI        Unreviewed;      1080 AA.
AC   A0A1M5DM66;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN05444320_104516 {ECO:0000313|EMBL:SHF67974.1};
OS   Streptoalloteichus hindustanus.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Streptoalloteichus.
OX   NCBI_TaxID=2017 {ECO:0000313|EMBL:SHF67974.1, ECO:0000313|Proteomes:UP000184501};
RN   [1] {ECO:0000313|EMBL:SHF67974.1, ECO:0000313|Proteomes:UP000184501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44523 {ECO:0000313|EMBL:SHF67974.1,
RC   ECO:0000313|Proteomes:UP000184501};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; FQVN01000004; SHF67974.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M5DM66; -.
DR   STRING; 2017.SAMN05444320_104516; -.
DR   Proteomes; UP000184501; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd19067; PfuEndoQ-like; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 2.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000184501}.
FT   DOMAIN          499..757
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          758..1080
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          435..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          551..578
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        443..460
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         520..527
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1080 AA;  117659 MW;  77C4F2B1A7160379 CRC64;
     MSRSRGKISR VRFHADLHIH SKYSRACSRD CDLEHLTWWA RRKGITLVGT GDFTHPAWFD
     HLRENLVPAE PGLFRLRPEL DAAIGRTLPA SCAGEVRFLL SVEISTIYKR DDRTRKVHHL
     LYAPDLQVAA AINARLARIG NLGADGRPIL GLDSRHLLEI TLEAGGYLVP AHVWTPWFAV
     LGSKSGFDAV EDCYADLAEH VFAVETGLSS DPAMNWRVSG LDRYRLVSNS DAHSPPMLGR
     ETTVFDTDLD YFAVRRALET GQGFAGTVEF FPEEGKYHLD GHRKCDVRLE PADTRAREGR
     CPECGKPLTV GVLHRVEELA DRPEGARPAG AGEFRSLVPL PEIMSEILGV GPRSKTVLGE
     IATLTAALGP ELAILDQVPV ADIAPHSAPL AEAVARLRRG QVIRDAGYDG EYGTIRLFEP
     GELRRATLHA VPSLFDDEAF PDPTPTPAAP QAPTPAATAS PAPAGPEAST GEQGMPEASP
     DPTGGVAGDD EVPRASLLDG LDPDQRAAAA TTTGPLLIIA GPGTGKTRTL THRLAHLVAT
     GQAAPEHCLA ITFTRRAAEE MSERLAALTD RARHLTVATF HSLGLRILRE QHARAGLSAD
     FGVADEARRL ALLTELTGDE RQARRAAAAL SRPGDEADPE LAELRQRHTK ALRERDLVDL
     DDLVRLPVEI LTADPGLTAA YRDRYRWICV DEYQDVDDTQ YQLLRLLAPP DGNITAIGDP
     DQAIYRFRGA DVGFFLRFTT DFPGARTVQL TRNYRSTPPI LSGALQAIAP TSLVPDRVLT
     PAVEHPDSPP LGLHQAADEQ AEAAFVARTI DQLLGGSSFH SLDSGRAEGH DGHELSFADI
     AVLYRTDSQA RALLDALTRA GVPVQKRSHD RLADRPGVRD ILRELTFRPD TSGGEPVGER
     VVDRVRLAAR AALALAPERD REAHAAEVHS ALDLLGPLAT RCGHDLDRFH TELVTGAEVD
     TWDPHADLVS LLTLHAAKGL EFPVVFLVGC EDGLLPLRWP GAEDTEAAEA VREERRLFFV
     GMTRARRHLY LSHAARRARH GSARPAAPSP FLADIDPALC QRVGDPAPRR RPRSQQLRLL
//
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