UniProt: A0A1M5FHS1

Database: UniProt
Entry: A0A1M5FHS1_9FLAO

LinkDB:  A0A1M5FHS1_9FLAO 
Original site:  A0A1M5FHS1_9FLAO

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Ontology (3)   
   GO (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (15)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (2)   
   SMART (2)   
All databases (20)   

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ID   A0A1M5FHS1_9FLAO        Unreviewed;       450 AA.
AC   A0A1M5FHS1;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   ORFNames=SAMN05444396_102401 {ECO:0000313|EMBL:SHF91117.1};
OS   Flavobacterium segetis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=271157 {ECO:0000313|EMBL:SHF91117.1, ECO:0000313|Proteomes:UP000184036};
RN   [1] {ECO:0000313|Proteomes:UP000184036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19741 {ECO:0000313|Proteomes:UP000184036};
RA   Varghese N., Submissions S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362011}.
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DR   EMBL; FQWE01000002; SHF91117.1; -; Genomic_DNA.
DR   RefSeq; WP_072988651.1; NZ_FQWE01000002.1.
DR   AlphaFoldDB; A0A1M5FHS1; -.
DR   STRING; 271157.SAMN05444396_102401; -.
DR   OrthoDB; 9790355at2; -.
DR   Proteomes; UP000184036; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        318..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        359..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        386..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          140..203
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          145..205
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   DOMAIN          204..260
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   450 AA;  49896 MW;  F10B7F329E09D998 CRC64;
     MEFKISKGLI QELELLIQNK NDQQLELLLN DLHHADIAEI LDELDFNEAT YIFKVLDSEK
     TAEILLELED DLRENILSRL SPKEIAEELD ELETNDAADI IAELSQDLKA EVISELQDVE
     HAKDIVDLLR YDEDTAGGLM HKELVKVNEN WNVLTCVKEM RIQAENISRV HSIYVVDDED
     RLKGRLSLKD LLTTSSRTPI NDVYITKLNF VKVDTEDVEV ARIMQRYDLE AIPVVDELGR
     LVGRITIDDI VDVIKDEADE DYQLAAGISK DIEADDSIFE HTKARLPWLV LALLGGFISV
     KVLGLFEGAM LEHGNLFFFT PLIAAMAGNV GVQSSAIIVQ GLANNTLSGS LFSRLVKEVS
     LSLLNGVILA TILFLGSHFL LNVEVIIGVI VTTALISVII IASLIGTFIP LLLDKFGIDP
     ALATGPFITT SNDICGILIY FSIAKIILGF
//

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