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Database: UniProt
Entry: A0A1M5GAX8_FLAFR
LinkDB: A0A1M5GAX8_FLAFR
Original site: A0A1M5GAX8_FLAFR 
ID   A0A1M5GAX8_FLAFR        Unreviewed;      1189 AA.
AC   A0A1M5GAX8;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   08-MAY-2019, entry version 15.
DE   RecName: Full=Histidine kinase {ECO:0000256|SAAS:SAAS00924638};
DE            EC=2.7.13.3 {ECO:0000256|SAAS:SAAS00924638};
GN   ORFNames=SAMN05444481_101443 {ECO:0000313|EMBL:SHG00859.1};
OS   Flavobacterium frigidimaris.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=262320 {ECO:0000313|EMBL:SHG00859.1, ECO:0000313|Proteomes:UP000184521};
RN   [1] {ECO:0000313|EMBL:SHG00859.1, ECO:0000313|Proteomes:UP000184521}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15937 {ECO:0000313|EMBL:SHG00859.1,
RC   ECO:0000313|Proteomes:UP000184521};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; FQWG01000001; SHG00859.1; -; Genomic_DNA.
DR   Proteomes; UP000184521; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00156; REC; 2.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF13185; GAF_2; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00072; Response_reg; 3.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 3.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 3.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 3.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS01002602};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000184521};
KW   Kinase {ECO:0000256|SAAS:SAAS00924871};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01002785};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Transferase {ECO:0000256|SAAS:SAAS00924820};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM    178    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      220    272       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      525    746       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   DOMAIN      799    912       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      921   1037       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN     1068   1185       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   COILED      140    174       {ECO:0000256|SAM:Coils}.
FT   COILED      432    515       {ECO:0000256|SAM:Coils}.
FT   MOD_RES     848    848       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   MOD_RES     970    970       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   MOD_RES    1118   1118       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   1189 AA;  134084 MW;  A6A67A0142866142 CRC64;
     MKNNFKRNLL ISSLISLLVL TVSSTASFLS IKSLLNSNFW VNHTQDVIYN LNEGSAIITE
     AQTSMRGYLI TGDEQFITRY NDAEVKSNSY FEKVSELTLD NPAQQTQLNE LKTLRSNFFK
     YLNNQIVKKR LGKNAATFDL TEGRNMMNDL RGQIKKIENT EQNLLKERND NSERYGKYSI
     ILIIVAFVIA FIISIVFLIR ILKDFNERAL LQAELEKKDR ETAQRIEAIS SIASNISNGN
     YDIRVDDTKA DALGSVGESL NSMGISLKSS FDLLSQKEWL QTGIASLNNV MLGDKSLQKL
     SKDVIEFVCQ YTNSSAGVLY VLEENELYVA GGYSYIPSKN RERIQKGEGL IGQAIVSGKI
     LQLKALSPDD IQINYALGQI KPTHIVAIPL LDTRVEGAIE LASIYGFSDL HLEFLKSVSN
     NIGIAIKSTQ NRKRVLELLE ETKSQSEELQ VQHSELEAIN AELEAQTEKL QASEEELRVQ
     QEELEQTNEE LSERSVLLEE KNNEIQKKSE ALELTTRYKS EFLANMSHEL RTPLNSILLL
     SRLLSENNNK SMVEEEIEFA KVIQSSGNSL LGLIDEILDL SKIEAGKMEL EFLDVSTKEI
     TDTLWNLFNQ VAKEKGIKFE ILSKDAPIVI KTDKMRLEQI LKNLISNAIK FTEKGTVSLE
     IKINEDDDKI ICFIVKDTGI GIPLEKQPLV FEAFQQADGS TKRKYGGTGL GLSISRELAK
     LLRGEIILHS KVQEGSTFTL CLPVFGSAIH KINVERIPPT EFTEVEETEK APVKNKYLSA
     TIPDEIEDDR NSILPTDKVI LIVEDDINFA KSLLTFTRKK GYKGVVSVRG DYALNFTLLY
     KPVGVLLDIE LPIKSGWEVL EELKNHSETK HIPVHIMSSH KLKQESLLKG AVDFLDKPVA
     FEKIPDVFLR IEHIINKEAQ KVLIIEDNPK HAKALAYFLE TYNINSEIKS EVSQGLDALN
     KTEVDCVILD MGIPDKHAYQ ILDGVKKSPG LENLPVIVFT GKSLSMKEEV KIKKYADSII
     VKTAHSYQRM LDEVSLFLHL VEDKKEGNDK KESYKKLNLL NNILHEKKVL IVDDDVRNIY
     SLTKALEVFK MNVITAFDGK EAIKILAEHP DTDIVLLDMM MPNMDGYETA EKIRANPKFL
     NLPVIAVTAK AMTGDREKCI KAGASDYITK PVDIDQLLSL LRVWLYDKI
//
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