ID A0A1M5HB48_9BACT Unreviewed; 755 AA.
AC A0A1M5HB48;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Transporter, CPA2 family {ECO:0000313|EMBL:SHG13088.1};
GN ORFNames=SAMN05444362_1164 {ECO:0000313|EMBL:SHG13088.1};
OS Dysgonomonas macrotermitis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Dysgonomonas.
OX NCBI_TaxID=1346286 {ECO:0000313|EMBL:SHG13088.1, ECO:0000313|Proteomes:UP000184480};
RN [1] {ECO:0000313|Proteomes:UP000184480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27370 {ECO:0000313|Proteomes:UP000184480};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; FQUC01000016; SHG13088.1; -; Genomic_DNA.
DR RefSeq; WP_062182857.1; NZ_FQUC01000016.1.
DR AlphaFoldDB; A0A1M5HB48; -.
DR STRING; 1346286.SAMN05444362_1164; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000184480; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 580..664
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 670..755
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 755 AA; 82966 MW; 026D2B5174FE0150 CRC64;
MSHLPPLVSD LALILITAGI VTIIFKLLKQ PVVLGYIVAG FLISPHFGLI PNIVDMSNIS
AWAEIGVIFL LFALGLEFSF KKLMDVGGTA SIATLVNMGS MIVIGYILGQ LMGWTQMESV
FLGGMLSMSS TTIIIKAFND MGLQKKKFAG IVFGMLIVED LAAILMMVLL STVAKSNHVE
GAGLLESILR LGFFMVIWFV VGIYLIPSFL KRFKKYLNDE TMLIVAVGLC LGMVLFADSV
GFSAALGAFI MGSILAETIE SKHIEHLIEP IKNLFGAVFF VSVGMMIAPG IVAEYIVPIL
LLTVVVLIGR VIFATLGVVA SGEGLKVSLQ AGFSLAQIGE FSFIIATLGM QLGVISDFIY
PIIVAVSVIT TFTTPYCIKL SEPVYHALEK VIPDKWGKLI TGYAESNRKT VNHQTDWNIL
LKNVLSTVAI YFTLSLAVYF FSNNFIIPYV IDYIHGIWGH ILAGLVTLLL MAPFMRSIMR
RKSRSEEAKK LWKDSNFNKG ALIALETLRI ALCVVLILMV LIPLFPRATG ILLLVSGAIA
TFLIFSNGFK SQSQRMEKQF FRNLNDKELT EESQKAVEKN AKTKLLSKNI HIEKIDVPQN
SPRVGKTLAE LNFKQSTGVD IVSIVRGDQR INIPDGNVRL YPFDRLVVAG TDEELQDLIT
ALDEKNNKEH QPESATVNGQ IVVSQYELEE GCPLIGKLIK ESKIKDKADC MIISIDRDGE
AMVSFGADTV LQVGDVLWLA GEKEKLEKFE DNISA
//
