ID   A0A1M5I8G0_STRHI        Unreviewed;       258 AA.
AC   A0A1M5I8G0;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
GN   ORFNames=SAMN05444320_107158 {ECO:0000313|EMBL:SHG24507.1};
OS   Streptoalloteichus hindustanus.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Streptoalloteichus.
OX   NCBI_TaxID=2017 {ECO:0000313|EMBL:SHG24507.1, ECO:0000313|Proteomes:UP000184501};
RN   [1] {ECO:0000313|EMBL:SHG24507.1, ECO:0000313|Proteomes:UP000184501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44523 {ECO:0000313|EMBL:SHG24507.1,
RC   ECO:0000313|Proteomes:UP000184501};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC         Evidence={ECO:0000256|RuleBase:RU000544};
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR   EMBL; FQVN01000007; SHG24507.1; -; Genomic_DNA.
DR   RefSeq; WP_073486486.1; NZ_FQVN01000007.1.
DR   AlphaFoldDB; A0A1M5I8G0; -.
DR   STRING; 2017.SAMN05444320_107158; -.
DR   OrthoDB; 9781579at2; -.
DR   Proteomes; UP000184501; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR   PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR   Pfam; PF00265; TK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000544};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184501};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
SQ   SEQUENCE   258 AA;  28195 MW;  D04B8F72DCC05C6F CRC64;
     MSTLPDPTDA LSAVPAASAR RAVPVTGRLR FFYGPMDCGK STLALQIDHN HARQGRRGVL
     LVRHDRSGLP QISSRIGITR GAVEVDERDD LRELVRARWA LGQHVDYLIV DEAQFLSAEQ
     VEQLAELADD VHLDIYCFGI ATDFRSELFP GSRRLFELAD DLQAVQVEVL CWCGLPGRFN
     ARVVAGRVVR AGDTVLVADT SAASTVRGQS DTGETITEGA EDAETAPATV RYQVLCRKHY
     RLGDLGPVVA REGQLSLT
//