ID A0A1M5IID5_9GAMM Unreviewed; 507 AA.
AC A0A1M5IID5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN04487965_3675 {ECO:0000313|EMBL:SHG28027.1};
OS Microbulbifer donghaiensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=494016 {ECO:0000313|EMBL:SHG28027.1, ECO:0000313|Proteomes:UP000184170};
RN [1] {ECO:0000313|EMBL:SHG28027.1, ECO:0000313|Proteomes:UP000184170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7063 {ECO:0000313|EMBL:SHG28027.1,
RC ECO:0000313|Proteomes:UP000184170};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FQVA01000012; SHG28027.1; -; Genomic_DNA.
DR RefSeq; WP_073277923.1; NZ_FQVA01000012.1.
DR AlphaFoldDB; A0A1M5IID5; -.
DR STRING; 494016.SAMN04487965_3675; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000184170; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:InterPro.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..148
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 163..471
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 468..502
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 507 AA; 57523 MW; C2636EEE0B6F2BBF CRC64;
MNDKINQDSI NKALWNACDT FRGTISADTY KDFILTMLFL KYISDVWQDH YEAYQAEYGD
EPELLEEMMK NERFVLPKSA SFYALWERRH EPGNGERIDQ ALHAIEEANG TKLKDAGKSV
FQDISFNTDR LGEEKQKNTI LRHLLEDFAK PELNLKPSRV GSLDVIGNGY EYLIKNFAAS
GGQKAGEFYT PPEVSDLIAE LLDPQPGDSI CDPACGSGSL LMKCGRKVVD KHNSKQYALY
GQEAIGSTWS LAKMNMFLHG EDNHKIEWGD TIRNPKLLDK NGDLMLFDIV TANPPFSLDK
WGHDEAEHDK FGRFRRGVPP KTKGDYAFIL HMIETLKPKS GRMGVVVPHG VLFRGSSEGK
IRKQLIEENL LDTVIGLPEK LFYGTGIPAA ILIFSRNKAD DSVMFIDASR EFKAGKNQNL
LTEDNIRKIV ATYETGADVD KYAYVADLDE IRENEYNLNI PRYVDTFEEE EEIDLLAVRA
ERERLRAQLN ELEGEMTKFL EELGYGA
//
