ID   A0A1M5IVT6_9BACT        Unreviewed;      1192 AA.
AC   A0A1M5IVT6;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN05720760_10896 {ECO:0000313|EMBL:SHG32396.1};
OS   Fibrobacter sp. UWB8.
OC   Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC   Fibrobacter.
OX   NCBI_TaxID=1896207 {ECO:0000313|EMBL:SHG32396.1, ECO:0000313|Proteomes:UP000184492};
RN   [1] {ECO:0000313|Proteomes:UP000184492}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UWB8 {ECO:0000313|Proteomes:UP000184492};
RA   Varghese N., Submissions S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FQVZ01000008; SHG32396.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M5IVT6; -.
DR   Proteomes; UP000184492; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          1..412
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          413..707
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         22..29
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1192 AA;  136027 MW;  3BF2098D0D605EDA CRC64;
     MTQIKLFNID DFHLGNNLYI DASAGTGKTY TIQQLVAKLV RGENGRAGIP LSKILIVTYT
     DKATGELRDR IRQKMEDCLA EENLECYREA LQNIHTAPIF TIHSFCQKVL HDFAYEAGSS
     FNLEVVSDDG IENLIQRLIR DKWSFETEFM NMLNSSKFKM NLFVKNFVNA AKFMLQNREA
     KKFEPDYSTL EGILQWAPGA RNAWNVLLKN KDKTYEEVLK TKTNLLKLSD FIAAIKAYKG
     DDKLFPRTFT KKWRGVWESD ELNAAVDFFF DLKDMDLQKA ALEVFQKFIF DHVKDLVELW
     QKEKREGKAQ SFSDMINDVH ESVLNGSGEL VQKLRETYRY AIIDEFQDTN QLQWDIFKTI
     FLESPDNNIV VVGDPKQSIF SFQGADVGVY RHAIAEIGEK NGRRLSTNYR SSDDIIEACN
     ELFQGDFLEN GDFSKSDVPV DKLKKQPPVL NGEKTAPLWI SNVSDEYEFA EFAVRKIVEC
     CAPSAGDPSK TSLRVFDKDE KELRNVRFSD FAILSRTRSE MTALESAMAQ VGIPYTRYKD
     TNLFYGKECA HWISLLKALD APDFSSWNRK FLNEALITDF FRVPLERVED ESFIYPTGDI
     MKLFVGWRQL VAKGRWAELQ ESIYQETEID KYLSTPATLQ QLAKVKQIGT YIFDYLYNNQ
     VSLEEVIKHL QGLANSSEDV DDADGNLVAK GSDFDAVNLM TIHASKGLAF PIAIITGGLR
     GDNYRKEREP FSFDYEGQKY IGFDAGVSSE TSKRENHAEW RRLIYVAYTR AESLMIVPQY
     KIWFEDDGKT VKPNKPFAFL ANAIARLSET DFARTCQDDS HADSYATASA SQLKKMVAQI
     LRNTKDEKPD DSRLPDFESL QNKVNDACIY QYSYSSLASK KRVLENREDF YDNGEISVDG
     NRANREDFIE AGSGTNSILI DDASALVQPC ANYDKNAPVA GVANYPRGAN LGDALHKVFE
     NLDFETVGNL PDENAAREDA TLRNLIAETY QGNSIHIQEH PEWNDLTAGF IWNTMNAELP
     EIHGSIATGK TFRLKDLPAA MRRAEMGFHL DSHGEESSWM NCLCKGFIDL MFVRKGDDGE
     DYYSILDWKS DVMDDADYSD KDALSQKIEE EYSIQRVLYS YLLIKWLKQF YGEDEPQIFE
     KHFGGIYYAL ARGTNAGTCN GIYCQTWKSY SDLEKSYRNV AALMKRSTKE SA
//