ID A0A1M5J7K3_9ALTE Unreviewed; 395 AA.
AC A0A1M5J7K3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Membrane fusion protein, macrolide-specific efflux system {ECO:0000313|EMBL:SHG36596.1};
GN ORFNames=SAMN05216361_1979 {ECO:0000313|EMBL:SHG36596.1};
OS Marisediminitalea aggregata.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Marisediminitalea.
OX NCBI_TaxID=634436 {ECO:0000313|EMBL:SHG36596.1, ECO:0000313|Proteomes:UP000184520};
RN [1] {ECO:0000313|Proteomes:UP000184520}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.8995 {ECO:0000313|Proteomes:UP000184520};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; FQWD01000003; SHG36596.1; -; Genomic_DNA.
DR RefSeq; WP_073321725.1; NZ_FQWD01000003.1.
DR AlphaFoldDB; A0A1M5J7K3; -.
DR STRING; 634436.SAMN05216361_1979; -.
DR OrthoDB; 9791520at2; -.
DR Proteomes; UP000184520; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR Gene3D; 6.20.50.140; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000184520}.
FT DOMAIN 51..294
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 369..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..137
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 395 AA; 42653 MW; 49A75186FC0FE84D CRC64;
MLKGYGPVIK IALLLIIIGA PAYALYSIYA PAANDEAQLL APVRRGDIET TIVATGQLEP
KRYVEVGAQV SGQVDAIYVE EGDVVTEGQL LVDIDATVFR TQVQKTEANL ENKRAQLEQL
KAERELAILR AKRNERLHAQ DAVSEDEVYA SQTNVRVLDS KISASIAQIK ADEASLEGDR
ATLGFAKIYA PIAGTVATIK VRQGQTLNAN QNAPTLLQIS DLNTMTVRAE VSEADVGKLY
PGMPVYFTTL GDTRTRYHST VRQVLPTPNV VNDVVLYQVL IDIQNDSGAL MDAMTTQVFF
VQEQKTDTLL VPLAAIKGPP RNPFVLVVTE QGNEQRQVKV GIRNRTVAEI LDGLSEGEQV
VVGVRGAAAR GQRGQQNGPP GMPPGMPGGG RRGGF
//
