ID   A0A1M5LW04_9ALTE        Unreviewed;       511 AA.
AC   A0A1M5LW04;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SHG69186.1};
GN   ORFNames=SAMN05216361_2810 {ECO:0000313|EMBL:SHG69186.1};
OS   Marisediminitalea aggregata.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Marisediminitalea.
OX   NCBI_TaxID=634436 {ECO:0000313|EMBL:SHG69186.1, ECO:0000313|Proteomes:UP000184520};
RN   [1] {ECO:0000313|Proteomes:UP000184520}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.8995 {ECO:0000313|Proteomes:UP000184520};
RA   Varghese N., Submissions S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; FQWD01000004; SHG69186.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1M5LW04; -.
DR   STRING; 634436.SAMN05216361_2810; -.
DR   Proteomes; UP000184520; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000184520}.
FT   DOMAIN          7..187
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          189..286
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          417..500
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   511 AA;  55376 MW;  14097D3902AEE1CB CRC64;
     MHTIQHTGVV GAGAMGRGIA QVLLANGKNV VLVDTQVEAL TSARDDIHAM LSKQAAKGRL
     TGISVEQTMN NLSLAQTDAL DQLARCDLIV EAIVERYDAK IALFQQLETL VAEHCILATN
     TSSLSVTQIA AGCANPERVV GWHFFNPVPL MRLAEVIGAL QTRADVVEQI VALTHAIGHT
     PVTVKDMPGF LVNHVGRGYG GEALHVLAEQ VADIAQIDRI LTAQCGFKMG PFTLFDLTGL
     DISHKVTESI YQQFYHDPRY RPSPLAEQRV QAGLLGRKTG KGFYTYTDGK QQIPEQPATP
     SLDDIKAMPV WIAGRGSNEH KQVLQLLSNT NAVIEQGKEP SEDALIIISP WGTDASGYAF
     EHGLDATRTI AVDPLFPDTD ICVLMRTQAT RSDVAQFAHA LFASTGKQVE VINDSYGFVS
     QRVLACIINI ACDMVHKDIA SAADIDRAMQ LGLGYPQGAF AWASQIGPAN VLTLLQRLFA
     QSGDPRYRPS IWLQREIQTN AQTGKPLIQG A
//