ID A0A1M5MIC2_9FLAO Unreviewed; 381 AA.
AC A0A1M5MIC2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase {ECO:0000256|ARBA:ARBA00013253};
DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253};
GN ORFNames=SAMN05444372_109175 {ECO:0000313|EMBL:SHG76473.1};
OS Flavobacterium micromati.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=229205 {ECO:0000313|EMBL:SHG76473.1, ECO:0000313|Proteomes:UP000184020};
RN [1] {ECO:0000313|Proteomes:UP000184020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17659 {ECO:0000313|Proteomes:UP000184020};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC dihydroneopterin triphosphate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00005051}.
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DR EMBL; FQWF01000009; SHG76473.1; -; Genomic_DNA.
DR RefSeq; WP_073020301.1; NZ_FQWF01000009.1.
DR AlphaFoldDB; A0A1M5MIC2; -.
DR STRING; 229205.SAMN05444372_109175; -.
DR OrthoDB; 9776634at2; -.
DR UniPathway; UPA00077; UER00155.
DR Proteomes; UP000184020; Unassembled WGS sequence.
DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01673; dNK; 1.
DR CDD; cd00483; HPPK; 1.
DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR000550; Hppk.
DR InterPro; IPR035907; Hppk_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01498; folK; 1.
DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR43071:SF1; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF01712; dNK; 1.
DR Pfam; PF01288; HPPK; 1.
DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SHG76473.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000184020};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..134
FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase"
FT /evidence="ECO:0000259|Pfam:PF01288"
FT DOMAIN 183..376
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 381 AA; 44448 MW; 2AEF4C350A0A1895 CRC64;
MKSQHQVILS VGSNQGNRLE NIENCIVLLH KAVGTVIKVS RLYETPSWGF DSDSFFNCAL
LIHSSNSAQK VLNQVLKIEK KLGRVRSGVV GYESRIIDID IIAFDEEIIN SDKLQVPHRL
MQNRNFVLLP CQDLKLDWKH PIFKKTIVEL LKESPDESIC NVVQYLKFPL QSIALEQFNY
VAFEGNIGAG KTTLATKIAE DFNAKTVLER FADNPFLPKF YKDQNRYAFP LEMSFLADRY
QQLSDDLAQF DLFKDFIVAD YHIFKSLIFA KITLADDEYR LYRNLFDIIY KEMPKPDLYV
YLYQNSERLL QNIKKRGRSY EQKIAADYLD KINNGYLDYI KSQTDLNVLI IDVSDRDFVK
NQEDYIFILN EIQKKITHKQ N
//
