ID A0A1M5P6L6_STRHI Unreviewed; 770 AA.
AC A0A1M5P6L6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Multicomponent Na+:H+ antiporter subunit A {ECO:0000313|EMBL:SHG97398.1};
GN ORFNames=SAMN05444320_11788 {ECO:0000313|EMBL:SHG97398.1};
OS Streptoalloteichus hindustanus.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Streptoalloteichus.
OX NCBI_TaxID=2017 {ECO:0000313|EMBL:SHG97398.1, ECO:0000313|Proteomes:UP000184501};
RN [1] {ECO:0000313|EMBL:SHG97398.1, ECO:0000313|Proteomes:UP000184501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44523 {ECO:0000313|EMBL:SHG97398.1,
RC ECO:0000313|Proteomes:UP000184501};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
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DR EMBL; FQVN01000017; SHG97398.1; -; Genomic_DNA.
DR RefSeq; WP_073489832.1; NZ_FQVN01000017.1.
DR AlphaFoldDB; A0A1M5P6L6; -.
DR STRING; 2017.SAMN05444320_11788; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000184501; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1200; NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ; 1.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184501};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 75..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..103
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 123..408
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 591..655
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 676..749
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
SQ SEQUENCE 770 AA; 80362 MW; 8D412B45AB8CC61F CRC64;
MLILVIAHLV VAALVPPAAR RWGPRALLAF AALPTAALAW TLTRAPGVLA GEAVRETVKW
AGTLDLSFAF RLDPLALLVL LLVTGVGAAV LVHGAYYLDD ADAGRVGALL LVFAGAMVGL
VTADHLITLY VFWELTTVCS FLLIGGVGAT RAERKAALQA LLVTALGGLL MLLGLVMLGE
AAGTYRLSAI LSAPPRGGLV EAALALVLVG AFTKSAQLPF HPWLPAAMVA PTPVSAYLHA
AAMVKAGVYL VARWTPAFAD VPFWRPAVLV VGLLTLLVGA WRALAETDLK RLLAFGTVSE
LGLLMVLFGA GTPVAASAGA AMLLAHGAFK AALFLLTGVL DHQLGTRDAR ELSGVARTFP
GLAAVAVLAA ASMAGLPPLV GFLGKEASYE AFAGDPVVLA PLVLGSVLTV AYSVRFLWGG
FATKPGVKAS AGQRPTIGFV LPPAVLAAAG LLLGLWPGLT DDLARGYANG YGPTQEYHLA
MWHGFTAPLL FSAVALVAGV GVGWAWDRLA ALRARLPRAP EAQRGYEYGV RGLDALALQL
TRRTQVGSLP LYLTVILLVV LAGPGLLLAL HAPTSVPATM NGLVVQVPLG VLVLAAAIAV
PRARHRLSAV LLTGVVGYGV AGLFVAHGAP DLALTQFLVE TLVLVVFALV LRRMPVRFTP
LRRGWRLHWP RWLAAGGVGL MVGAFALRAA AARDQPAISH AYLDHAEQAG AHNVVSAVLV
DFRALDTLGE IGVLAVAAVG VASLVVGARR PRRGQEQERE REREREEVPR
//
