ID A0A1M5P915_9ACTN Unreviewed; 360 AA.
AC A0A1M5P915;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Isopenicillin N synthase {ECO:0000313|EMBL:SHG97939.1};
GN ORFNames=SAMN05443575_3004 {ECO:0000313|EMBL:SHG97939.1};
OS Jatrophihabitans endophyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Jatrophihabitantales;
OC Jatrophihabitantaceae; Jatrophihabitans.
OX NCBI_TaxID=1206085 {ECO:0000313|EMBL:SHG97939.1, ECO:0000313|Proteomes:UP000186132};
RN [1] {ECO:0000313|EMBL:SHG97939.1, ECO:0000313|Proteomes:UP000186132}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45627 {ECO:0000313|EMBL:SHG97939.1,
RC ECO:0000313|Proteomes:UP000186132};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000256|RuleBase:RU003682}.
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DR EMBL; FQVU01000004; SHG97939.1; -; Genomic_DNA.
DR RefSeq; WP_073391245.1; NZ_FQVU01000004.1.
DR AlphaFoldDB; A0A1M5P915; -.
DR STRING; 1206085.SAMN05443575_3004; -.
DR OrthoDB; 21825at2; -.
DR Proteomes; UP000186132; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR47990; 2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED; 1.
DR PANTHER; PTHR47990:SF258; FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR PRINTS; PR00682; IPNSYNTHASE.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Iron {ECO:0000256|RuleBase:RU003682};
KW Metal-binding {ECO:0000256|RuleBase:RU003682};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003682};
KW Reference proteome {ECO:0000313|Proteomes:UP000186132}.
FT DOMAIN 196..303
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 360 AA; 38951 MW; 4697A4A720145DB6 CRC64;
MGQQPTNGDS GPQDHGEPVV PVIDIGALVA GDAAGTATAV AQIDHACREI GFFQITGHGV
DPELVETMYT TSRRFFDLPL PAKRGVAQPN PETIRGYCAV GEQSFAYSDG IETPRDLHEK
FDVGPVDVPA DDPYYAPEHA GAHFLPNQWP AEPSGMEQVW TDYFHAMNDL CRLLMSAFAR
ALDLPADFFA DKIDKDISML RAINYPHSDQ PPLPGQLRAG AHTDYGSLTI VRQEEAPGGL
QVFTQDGDWL RVPVVPGAFV VNIGDLMAQW TNDLWISTRH RVANPPAGTG DTRRMSLVFF
HQPNYDAMVE CLPSCLSAGE QPRYEPIASG DHLMNKFVKT ISVEPAAGLA STVTPAGAGG
//
