ID A0A1M5PGN0_9FIRM Unreviewed; 367 AA.
AC A0A1M5PGN0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tyrosine lyase ThiH {ECO:0000313|EMBL:SHH00871.1};
GN ORFNames=SAMN04488530_11428 {ECO:0000313|EMBL:SHH00871.1};
OS Asaccharospora irregularis DSM 2635.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Asaccharospora.
OX NCBI_TaxID=1121321 {ECO:0000313|EMBL:SHH00871.1, ECO:0000313|Proteomes:UP000243255};
RN [1] {ECO:0000313|Proteomes:UP000243255}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2635 {ECO:0000313|Proteomes:UP000243255};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FQWX01000014; SHH00871.1; -; Genomic_DNA.
DR RefSeq; WP_073126020.1; NZ_FQWX01000014.1.
DR AlphaFoldDB; A0A1M5PGN0; -.
DR STRING; 1121321.SAMN04488530_11428; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000243255; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000313|EMBL:SHH00871.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000243255};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 70..297
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 367 AA; 42473 MW; 713FEB432CDE51A3 CRC64;
MSFYDVIERY REFDFDKYFE NVTDQDVLRS LSKDRLDDCD VLNLLSKTAE KHLEKMAQKA
HKLSVQYFGK TVCLYTPMYI ANYCINQCVY CSYNIKSGIK RKKLTMDEIK KEGDAISQEG
FKHLLVLTGE SSFHSSKEYI GEAIEILKDK FPSIGIEVYP METEDYKYIV EKGVEGLTVY
QETYDEDIYK KVHIKGPKSN YRFRLDAPER GAKAGMRTLS IGALLGLNDF RKETFFTILH
GKYLKKKYPH IELSYSTPRM RPFKGCFEEL VDISDKNLVQ AMVCMRLFDP HAAINISTRE
SLEMRKHIIP LGVTKLSAGV STDVGGHSQD EHSTSQFEIN DESGVKDIEK MLKSIGYQHV
FKDWERF
//
