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Database: UniProt
Entry: A0A1M5PHH1_9FIRM
LinkDB: A0A1M5PHH1_9FIRM
Original site: A0A1M5PHH1_9FIRM 
ID   A0A1M5PHH1_9FIRM        Unreviewed;       822 AA.
AC   A0A1M5PHH1;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=SAMN04488530_11439 {ECO:0000313|EMBL:SHH01168.1};
OS   Asaccharospora irregularis DSM 2635.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Asaccharospora.
OX   NCBI_TaxID=1121321 {ECO:0000313|EMBL:SHH01168.1, ECO:0000313|Proteomes:UP000243255};
RN   [1] {ECO:0000313|Proteomes:UP000243255}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2635 {ECO:0000313|Proteomes:UP000243255};
RA   Varghese N., Submissions S.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC       {ECO:0000256|ARBA:ARBA00005446}.
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DR   EMBL; FQWX01000014; SHH01168.1; -; Genomic_DNA.
DR   RefSeq; WP_073126038.1; NZ_FQWX01000014.1.
DR   AlphaFoldDB; A0A1M5PHH1; -.
DR   STRING; 1121321.SAMN04488530_11439; -.
DR   OrthoDB; 9763310at2; -.
DR   Proteomes; UP000243255; Unassembled WGS sequence.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:InterPro.
DR   CDD; cd17920; DEXHc_RecQ; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR   InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR029491; Helicase_HTH.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032284; RecQ_Zn-bd.
DR   InterPro; IPR018982; RQC_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   NCBIfam; TIGR01389; recQ; 1.
DR   NCBIfam; TIGR00614; recQ_fam; 1.
DR   PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR   PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00570; HRDC; 2.
DR   Pfam; PF14493; HTH_40; 1.
DR   Pfam; PF16124; RecQ_Zn_bind; 1.
DR   Pfam; PF09382; RQC; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00341; HRDC; 2.
DR   SMART; SM00956; RQC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50967; HRDC; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SHH01168.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000243255}.
FT   DOMAIN          26..195
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          219..363
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          518..598
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   DOMAIN          622..702
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   822 AA;  94364 MW;  D952220766376ACF CRC64;
     MNIKPLDILS KYYGYTSFRN GQESIINSII NKKDVLAIMP TGGGKSICYQ VPALCLDGIT
     IVISPLISLM KDQVDALKSM GIEAELINSS LSNNEYNQVL DNIENDRYKL LYVAPERLDS
     IEFINLIRNK DISQVAIDEA HCISSWGHDF RPSYKRIPQF IKRLNKRPIV TAFTATASDE
     VRYDIKSILD LQEPDVYITG FDRENLSINI VKSSSKNRYL LDYIENHKNE SGIIYVATRK
     EVESIYEGLL KRNYSVSKYH AGLNNEIRKE NQEKFINDEI KIMVATNAFG MGIDKFNVRW
     VIHYNMPQSI ENYYQEIGRA GRDGEPSECV LLFTPGDVHT QKYLVEVGID NPERKRIQYK
     KLQQMVDLVY SNGCYRKSIL NYFGDELEDK CDNCSNCLNE GEVIDKTLDA QKVISCIARM
     KRSFGTTMII DVLRGSKNKK VIDQKFNDLT TYGIMKNYGA EDLKTFINTL VAHGFLEVVE
     NMGVRGSYPT IKLNEQSMRV IKNEIKVEFK ESKVTKSRYV ENELYERLVG IRSEIARENR
     IAPYMVFGDA TLRNMASTYA VTKNEMLNIS GVGEVKYERY GYKFEEIIQK YIEEKNINKE
     EVLNTLETNK RTIAKDNEYF EVTTDSKLYE RLKDYRLSVS KLEGTLPYMV LGANTLKEIS
     GRYPLEEEQL KDIGGIGPVK ITKYGEDIIN IVKGHIEENN IIPKWEEKKR LKLVLDGDSR
     KTDEIVLDLL NQGNDIKEVC NETEVSLSTA LGYVCDYIKD GNDINFNINL KALYSENDKD
     MIKDAIDKFG YEKIGAIKKV LPDYIKYENI RAVILEGLLN DK
//
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