ID A0A1M5PJU9_9FLAO Unreviewed; 438 AA.
AC A0A1M5PJU9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN ORFNames=SAMN05443373_10687 {ECO:0000313|EMBL:SHH02062.1};
OS Flavobacterium granuli.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=280093 {ECO:0000313|EMBL:SHH02062.1, ECO:0000313|Proteomes:UP000184384};
RN [1] {ECO:0000313|Proteomes:UP000184384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19729 {ECO:0000313|Proteomes:UP000184384};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.88;
CC Evidence={ECO:0000256|RuleBase:RU361219};
CC -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate degradation;
CC (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.
CC {ECO:0000256|RuleBase:RU361219}.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
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DR EMBL; FQWO01000006; SHH02062.1; -; Genomic_DNA.
DR RefSeq; WP_072943574.1; NZ_PVUB01000002.1.
DR AlphaFoldDB; A0A1M5PJU9; -.
DR STRING; 280093.SAMN05443373_10687; -.
DR OrthoDB; 9764892at2; -.
DR UniPathway; UPA00257; UER00367.
DR Proteomes; UP000184384; Unassembled WGS sequence.
DR GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR Gene3D; 1.10.8.660; -; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|RuleBase:RU361219};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361219}.
SQ SEQUENCE 438 AA; 48898 MW; 403A96716FFEF6D9 CRC64;
MNKPVAGFSK LSKEEKINWI AKEYFSTPLE AITLLKNYWN SDEKIQKLHD EFIENTISNF
YIPLGVAPNF LINGKYQTIP MAIEESSVVA AAAKSAKFWS TRGGFKATVI NTEKIGQVHF
LFKGDVSKLE LFFAQTKAKF FSETKSITKN MQKRGGGILD IILKDKTDLL DNYFQLHATF
ETKDSMGANF INSCLEQFAK TLKQEAQSYE LFTASEKELQ VIMSILSNYV PNCIVRAEVS
CPIEDLAEKH ITNPQDFAER FVQAVQIAEV EPYRAVTHNK GIMNGIDAVV LATGNDFRAV
EAGIHAYAAK SGHYSSLSHA KIENGIFKFW LEIPLALGTV GGLTSLHPLV KLSLEMLENP
SAKELMQTVA VAGLAQNFAA LRSLTTTGIQ DGHMKMHLNN ILNQFEANED ERILIQKHFK
LNAVSHSAVV ELIENLRK
//
