ID A0A1M5Q5I1_9ACTN Unreviewed; 511 AA.
AC A0A1M5Q5I1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase {ECO:0000313|EMBL:SHH09507.1};
GN ORFNames=SAMN05443575_3306 {ECO:0000313|EMBL:SHH09507.1};
OS Jatrophihabitans endophyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Jatrophihabitantales;
OC Jatrophihabitantaceae; Jatrophihabitans.
OX NCBI_TaxID=1206085 {ECO:0000313|EMBL:SHH09507.1, ECO:0000313|Proteomes:UP000186132};
RN [1] {ECO:0000313|EMBL:SHH09507.1, ECO:0000313|Proteomes:UP000186132}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45627 {ECO:0000313|EMBL:SHH09507.1,
RC ECO:0000313|Proteomes:UP000186132};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FQVU01000004; SHH09507.1; -; Genomic_DNA.
DR RefSeq; WP_073391491.1; NZ_FQVU01000004.1.
DR AlphaFoldDB; A0A1M5Q5I1; -.
DR STRING; 1206085.SAMN05443575_3306; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000186132; Unassembled WGS sequence.
DR GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11645; Precorrin_2_C20_MT; 1.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR012382; CobI/CbiL.
DR InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01467; cobI_cbiL; 1.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 2.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 2.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SHH09507.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186132};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SHH09507.1}.
FT DOMAIN 9..222
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 268..473
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 511 AA; 53583 MW; ABCE621F72FFD0CF CRC64;
MAAPTGAGTL YGVGLGPGDP ELVTVRAARL IGAAHVVAYH SARHGRSVAR AIAEPYLRDG
QVEEQLVYPV TTETTEHPGG YEGAINDFYE AAAARLAEHL AAGRDVVLLA EGDPLFFSSY
MHMHKRIAGR FRTEIVPGVT SVSAAAAALA QPLVEGNDVL TVLPGTLPPD VLAERLAQTD
AAAIMKVSRH FAGVQDALKH AGRIEDAYYV ERASAASQRT ERAGDVDPAS VPYMSLVIVP
GPEAAQDPVA TATGGGTAAA PAGGRVDVVG LGPAGRDWLT PQAMAVLAAA DDVVGYSTYV
ARVPANPRQR RHASDNKVEA ERAEFALDLA RRGRRVAVVS SGDPGVFAMA SAVLEAATDE
RYAGVPVDIV PGLTAAQAVA SRAGAPLGHD YAVISLSDRL KPWDVVAARL DAAARADLAI
AIYNPASQTR RQQLHDARDV LLRHRDPVTP VVVGRAVGSD DETVTVTTLG ELDPETVDMR
CLLIVGSSQT RTLAVTGEPR VFTPRRYPAA D
//
