ID A0A1M5QNP7_9GAMM Unreviewed; 396 AA.
AC A0A1M5QNP7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN ORFNames=SAMN04488068_2709 {ECO:0000313|EMBL:SHH15223.1};
OS Hydrocarboniphaga daqingensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Nevskiales; Nevskiaceae;
OC Hydrocarboniphaga.
OX NCBI_TaxID=490188 {ECO:0000313|EMBL:SHH15223.1, ECO:0000313|Proteomes:UP000199758};
RN [1] {ECO:0000313|EMBL:SHH15223.1, ECO:0000313|Proteomes:UP000199758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7049 {ECO:0000313|EMBL:SHH15223.1,
RC ECO:0000313|Proteomes:UP000199758};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; FQWZ01000006; SHH15223.1; -; Genomic_DNA.
DR RefSeq; WP_072898191.1; NZ_FQWZ01000006.1.
DR AlphaFoldDB; A0A1M5QNP7; -.
DR STRING; 490188.SAMN04488068_2709; -.
DR OrthoDB; 9794902at2; -.
DR Proteomes; UP000199758; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199758}.
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 43048 MW; 5A4D1C2AF179D3CE CRC64;
MSQQPPPRVP VPRDRNDDYT EAAAQSRRDF LLQQRPGSRT DHIGHYSLPP SSLRGNVELF
AGVAQVPIGV AGPLRINGEH AQGDFYVPMA TTEGTLVASY NRGMRLIAEC GGVRTTVVEQ
HMQRSPVFFF SDARASRDFG HWIEDHLDGI RAAAEATTRF GKLIEVLQFA VGNLRYLRFN
YHTGDAAGQN MAGKATLAAC EWIRDTHPDH PRFMLSGNID TDKKHSQLNT LLTRGRRVIA
EATFTDEALR RIMKVSAQQL FEARQVSMTG AFMAGSASNG AHAANGLTAL FIATGQDVAN
VSESHSSLVY TQLLPNGDYY WSVTLPSLIV ATYGGGTGLA TQRECLELLG CYGSGKADRF
AEICAATVLA GETSLSSAVL AGDWVSSHDQ YGRNRP
//
