ID A0A1M5S4M5_9GAMM Unreviewed; 616 AA.
AC A0A1M5S4M5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Chaperone protein HscA homolog {ECO:0000256|HAMAP-Rule:MF_00679};
GN Name=hscA {ECO:0000256|HAMAP-Rule:MF_00679};
GN ORFNames=SAMN02745129_1870 {ECO:0000313|EMBL:SHH33537.1};
OS Ferrimonas marina.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Ferrimonadaceae; Ferrimonas.
OX NCBI_TaxID=299255 {ECO:0000313|EMBL:SHH33537.1, ECO:0000313|Proteomes:UP000184268};
RN [1] {ECO:0000313|EMBL:SHH33537.1, ECO:0000313|Proteomes:UP000184268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16917 {ECO:0000313|EMBL:SHH33537.1,
RC ECO:0000313|Proteomes:UP000184268};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chaperone involved in the maturation of iron-sulfur cluster-
CC containing proteins. Has a low intrinsic ATPase activity which is
CC markedly stimulated by HscB. {ECO:0000256|HAMAP-Rule:MF_00679}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|HAMAP-Rule:MF_00679,
CC ECO:0000256|RuleBase:RU003322}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQXG01000002; SHH33537.1; -; Genomic_DNA.
DR RefSeq; WP_067662954.1; NZ_FQXG01000002.1.
DR AlphaFoldDB; A0A1M5S4M5; -.
DR STRING; 299255.SAMN02745129_1870; -.
DR OrthoDB; 9766019at2; -.
DR Proteomes; UP000184268; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR CDD; cd10236; HscA_like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00679; HscA; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR042039; HscA_NBD.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR010236; ISC_FeS_clus_asmbl_HscA.
DR NCBIfam; TIGR01991; HscA; 1.
DR PANTHER; PTHR19375:SF176; CHAPERONE PROTEIN HSCA; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00679};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_00679};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00679}; Reference proteome {ECO:0000313|Proteomes:UP000184268}.
SQ SEQUENCE 616 AA; 66083 MW; 65B6A64E90B60932 CRC64;
MALLQIAEPG QAAAPHQHKL AVGIDLGTTN SLVAAVRSGE AATLPDEQGR HRMPSVVRFA
DEQVVTGHAA KAEAVQDPHN TIISVKRYLG RSLEDVTARY PNQPYQLKAS DNGLPLFVTR
QGEQNAIQIS AEVLRPLIQR AEATLGGDLS GAVITVPAYF DDAQRQGTKD AAELLGVKVL
RLLNEPTAAA IAYGLDSGQE GVIAVYDLGG GTFDISILRL NKGVFEVLAT GGDSALGGDD
FDHLLADYLA EQSGLDARDP ANQRRLLNEA CRVKEALSDQ DSVQAQLGDW QQTINVDHFN
ELIQPLIKRT LMACRRCLKD AGVAADEVLE VVMVGGSTRV PAVRNQIGDY FGRTPLTSID
PDRVVAIGAA IQADILVGNK PDSEMLLLDV LPLSLGLETM GGLTEKVIPR NTTIPVARAQ
EFTTYKDGQS AMAIHVVQGE REMVADCRSL ARFELRGLPA MAAGTAVVRV TFQVDADGLL
SVTAMEKTTG VQSSIEVKPA FGLSDAEVTQ MLTDSMTHAR EDLDKRMLTE QRIEAGRVIE
SLTKALEADG DILLAPEARQ ALEQRMRDLA ALCEGTDGEV IKQGIEALDN ASSEFAALRM
DLSIRRALSG QSVDNV
//
