ID A0A1M5TQ19_9CLOT Unreviewed; 916 AA.
AC A0A1M5TQ19;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN02745196_00671 {ECO:0000313|EMBL:SHH52799.1};
OS Clostridium collagenovorans DSM 3089.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121306 {ECO:0000313|EMBL:SHH52799.1, ECO:0000313|Proteomes:UP000184526};
RN [1] {ECO:0000313|EMBL:SHH52799.1, ECO:0000313|Proteomes:UP000184526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3089 {ECO:0000313|EMBL:SHH52799.1,
RC ECO:0000313|Proteomes:UP000184526};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FQXP01000003; SHH52799.1; -; Genomic_DNA.
DR RefSeq; WP_072830027.1; NZ_FQXP01000003.1.
DR AlphaFoldDB; A0A1M5TQ19; -.
DR STRING; 1121306.SAMN02745196_00671; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000184526; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000184526}.
FT DOMAIN 690..706
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 823..857
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 616..623
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 916 AA; 103565 MW; 61175B85B982E4B6 CRC64;
MALTPMMKQY LEVKETCKDA ILFFRLGDFY EMFFEDAEVA SKELELVLTG RDCGLENRAP
MCGIPFHSAE NYISRLVTKG FKVAICEQVE DPAFAKGIVK RDIVKILTPG TYMDASFLDE
SKNNFIMCIF KEDSSNVGGL SFADISTGEF YSTSGILKCG NILDEIAKFS PSEIIYNETL
EDNLLNEIKE RYNISLTKYS NEYYNEEALE SVKIQFKNYD SNRYDMEQLR SISSLIAYLK
YTQKNSLSHI DTLETYNIVD YLVIDTNSRM NLELTETLRD KSKKGSLLSV LDKTSTAMGA
RRLRKWIEEP LVDKILIEER QNSIEDLVNN LFVHEELKET LKDIYDIERL VGKISSKSVN
AKELMSLKNS IGKIPSVKEV IKPLTSSFYS NIYNNLDDLN DIYELLNKAL DDNPSISVKE
GNIIKTGYNE EVDSLREAKS SGKQWIASLE QEEKELTGIR SLKIGFNKVF GYYLEVTKSN
LSLVPTERYI RKQTLSNGER YITPELKEVE EKVLGAEEKL ITLEYELFAK LRDTIETHIE
RMKSVAKVIS EIDSLSSLAT VAVENNYVKP TINEEGIIDI KDGRHPVVEK LLSKNTFVEN
DTYLNTEEDQ LLLITGPNMA GKSTYMRQVA LLTLMAQMGS FIPVSSANIA ICDRIFTRIG
ASDDLASGKS TFMVEMWEVS NILKNATSKS LILLDEVGRG TSTYDGLSIA WAVIEFLCSD
NGIKAKTLFA THYHELIKLE QQIKGIKNYS VAVKEINNEI VFLRKIICGG TDESYGIEVA
KLAGIPTEVT DRAKEILSML ESENSSSASD NKITSVQSVN KVVVDNSKEV ELLQATIKEL
KEKINNLESL NKEVAMDMST SKKTKCKKQE NPMQMTFEDV EGKNLLKDIK ELDILSMNPM
EGFNKLYELV NKAKNL
//
