ID A0A1M5V4X3_9CLOT Unreviewed; 489 AA.
AC A0A1M5V4X3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN02745207_02080 {ECO:0000313|EMBL:SHH70230.1};
OS Clostridium grantii DSM 8605.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121316 {ECO:0000313|EMBL:SHH70230.1, ECO:0000313|Proteomes:UP000184447};
RN [1] {ECO:0000313|EMBL:SHH70230.1, ECO:0000313|Proteomes:UP000184447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8605 {ECO:0000313|EMBL:SHH70230.1,
RC ECO:0000313|Proteomes:UP000184447};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FQXM01000010; SHH70230.1; -; Genomic_DNA.
DR RefSeq; WP_073338367.1; NZ_FQXM01000010.1.
DR AlphaFoldDB; A0A1M5V4X3; -.
DR STRING; 1121316.SAMN02745207_02080; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000184447; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SHH70230.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000184447};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SHH70230.1}.
FT DOMAIN 3..212
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 265..480
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 489 AA; 54176 MW; 63B1986693922D84 CRC64;
MSKVYLMGVG PGDEELMTLK SVRVLKECTA VLYDRLAGGN ILKHINKDCK VFYVGKESGA
HYKTQEEIND LIIQLAKEGH IVGRVKGGDP YVFGRGGEEA LRLIEENIDF EVVPGITSAI
AVLNYAGIPI THRGMAQSFH VFTGMSAKNL NINWESVAAL EGTLVFLMGL GSLDEIIENL
VVRGKDKSTA CGVIMRGTTS KQKKVVGDLT DISDKVKKAG LKSPCIIVIG DVVQLHEQLN
WKEKQPLFGL NVCVTRTKEQ AKPVTEKLIS LGAEVTEINS IKIENTPENL KDYIKELENY
NHIVFTSVNG VNSFFDYLKN INYDIRKIKA KISSIGPATT DSIKNRGIIP EIQAKNFVAE
SLFESLKTEV NSGEKILIPR AKIARPYLVE ELRKLDCIVD EVHVYDTVTG DLVNKRAFED
VDVVLYTSPS TVRNMIKMVG LEELKMKKSL AIGPITNKEL QINGMEAVVC EEYSSQGLIE
KLLEIKEEA
//
